Although some fungi are deadly human pathogens, others have highly beneficial roles as producers of many life-saving drugs. In this Pearl, Ulrich Kück and colleagues discuss the various benefits of fungi—as both friend and foe to humans, most notably due to their antifungal and antibacterial properties.
The metal tug of war between pathogen and host is a complex and dynamic process, with each party striving to procure and retain essential micronutrients. In this Pearls article, Joanna Potrykus and colleagues discuss the subtleties of this intriguing aspect of fungal pathogen-host interplay.
Image Credit: Joanna Potrykus
In comparing the oral mycobiomes of HIV-infected and uninfected individuals, Mahmoud Ghannoum and colleagues found many differences. They show that HIV-positive individuals have less Pichia and more Candida fungi and that Pichia antagonizes growth of Candida and other pathogenic fungi, suppressing oral candidiasis in a mouse model.
The protozoan parasite Theileria annulata causes the often fatal leukoproliferative disorder Tropical Theileriosis in its ruminant host. Min Ma and Martin Baumgartner show that the parasite drives host cell motility and invasiveness through the induction and activation of the host MAP4K4 and subsequent changes to the cytoskeleton of the host cells.
Maternal Health Task Force is highlighting the work of numerous organizations around the world to improve maternal health. See more papers in PLOS Pathogens on the adverse effects of Malaria, Listeria, and Human Cytomegalovirus on maternal and fetal health.
Waterborne diseases remain a considerable burden to populations that lack access to a clean water supply or adequate sanitation. In observance of World Water Day this March 22, PLOS Pathogens highlights research that advances the understanding and treatment of waterborne diseases.