Alexaki and Wigdahl discuss HIV-1 replication within bone marrow, and suggest that the resultant infection of bone marrow hematopoietic progenitor cells may be involved in the early steps leading to the development of HIV-1-associated dementia (HAD) as an end result of this cellular trafficking process.
Amulic et al. describe an upstream open reading frame (uORF)–mediated mechanism used by parasites to repress translation of var2csa mRNA, thus providing a mechanism for controlling gene expression at the level of protein translation.
Cairns et al. test kinetic models of phage-bacteria interactions against data for Campylobacter jejuni, finding a successful model that explicitly allows for resistant bacteria that have not been accounted for in previous phage therapy theory.
Steel et al. use a guinea pig model to identify two specific residues in the viral polymerase that can contribute to efficient transmission of influenza virus, therefore suggesting one feature that contributes to the making of a pandemic influenza virus.
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