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Research Article

Cryoelectron Tomography of HIV-1 Envelope Spikes: Further Evidence for Tripod-Like Legs

  • Ping Zhu,

    Affiliations: Department of Biological Science and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, United States of America, Center for Structural and Molecular Biology and National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Chaoyang District, Beijing, China

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  • Hanspeter Winkler,

    Affiliation: Department of Biological Science and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, United States of America

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  • Elena Chertova,

    Affiliation: AIDS Vaccine Program, SAIC Frederick, National Cancer Institute at Frederick, Frederick, Maryland, United States of America

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  • Kenneth A. Taylor,

    Affiliation: Department of Biological Science and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, United States of America

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  • Kenneth H. Roux mail

    roux@bio.fsu.edu

    Affiliation: Department of Biological Science and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, United States of America

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  • Published: November 14, 2008
  • DOI: 10.1371/journal.ppat.1000203

Reader Comments (5)

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The correct number is 27% of the total spikes

Posted by mborgnia on 16 Nov 2008 at 02:35 GMT

representing 38% of total spikes
http://plospathogens.org/article/info:doi/10.1371/journal.ppat.1000203#article1.body1.sec3.sec1.p5

Based on the information conveyed in figure 3C, the total number of spikes in classes 4+6+8 is 785 (275+245+265), corresponding to ~27% of 2874 (the total number of spikes) and it is less than the number of spikes excluded during classification. Are all those 785 spikes included in figure 3A?