Advertisement
Research Article

Evolution of Multidrug Resistance during Staphylococcus aureus Infection Involves Mutation of the Essential Two Component Regulator WalKR

  • Benjamin P. Howden mail,

    Benjamin.Howden@austin.org.au

    Affiliations: Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia, Austin Centre for Infection Research (ACIR), Infectious Diseases Department, Austin Health, Heidelberg, Victoria, Australia, Microbiology Department, Austin Health, Heidelberg, Victoria, Australia, Department of Microbiology, Monash University, Clayton, Victoria, Australia

    X
  • Christopher R. E. McEvoy,

    Affiliation: Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia

    X
  • David L. Allen,

    Affiliation: Department of Microbiology, Monash University, Clayton, Victoria, Australia

    X
  • Kyra Chua,

    Affiliations: Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia, Department of Microbiology, Monash University, Clayton, Victoria, Australia

    X
  • Wei Gao,

    Affiliations: Austin Centre for Infection Research (ACIR), Infectious Diseases Department, Austin Health, Heidelberg, Victoria, Australia, Department of Microbiology, Monash University, Clayton, Victoria, Australia

    X
  • Paul F. Harrison,

    Affiliation: Victorian Bioinformatics Consortium, Monash University, Clayton, Victoria, Australia

    X
  • Jan Bell,

    Affiliation: SA Pathology, Womens and Children’s Hospital, Adelaide, South Australia, Australia

    X
  • Geoffrey Coombs,

    Affiliation: Microbiology Department, Royal Perth Hospital, Perth, Western Australia, Australia

    X
  • Vicki Bennett-Wood,

    Affiliation: Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia

    X
  • Jessica L. Porter,

    Affiliation: Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia

    X
  • Roy Robins-Browne,

    Affiliation: Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia

    X
  • John K. Davies,

    Affiliation: Department of Microbiology, Monash University, Clayton, Victoria, Australia

    X
  • Torsten Seemann,

    Affiliation: Victorian Bioinformatics Consortium, Monash University, Clayton, Victoria, Australia

    X
  • Timothy P. Stinear

    Affiliations: Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia, Department of Microbiology, Monash University, Clayton, Victoria, Australia

    X
  • Published: November 10, 2011
  • DOI: 10.1371/journal.ppat.1002359

Reader Comments (1)

Post a new comment on this article

Video link

Posted by BenHowden on 24 Nov 2011 at 00:23 GMT

study highlights the dramatic impacts of single mutations that arise during persistent S. aureus infections and demonstrates the role played by walKR to increase drug resistance, control metabolism and alter the virulence potential of this pathogen
http://plospathogens.org/article/info:doi/10.1371/journal.ppat.1002359#article1.front1.article-meta1.abstract1.p1

Please see the following link for discussion of this project and the role of whole genome sequencing in uncovering the resistance mechanisms:
http://www.youtube.com/watch?v=PqTpx8Rc2OY

No competing interests declared.