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Research Article

A Neutralizing Human Monoclonal Antibody Protects against Lethal Disease in a New Ferret Model of Acute Nipah Virus Infection

  • Katharine N. Bossart mail,

    kbossart@bu.edu (KNB); cbroder@usuhs.mil (CCB)

    Affiliation: CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia

    Current address: Department of Microbiology and National Emerging Infectious Diseases Laboratories Institute, Boston University School of Medicine, Boston, Massachusetts, United States of America

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  • Zhongyu Zhu,

    Affiliations: Protein Interactions Group, CCRNP, CCR, NCI-Frederick, NIH, Frederick, Maryland, United States of America, BRP, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, United States of America

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  • Deborah Middleton,

    Affiliation: CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia

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  • Jessica Klippel,

    Affiliation: CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia

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  • Gary Crameri,

    Affiliation: CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia

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  • John Bingham,

    Affiliation: CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia

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  • Jennifer A. McEachern,

    Affiliation: CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia

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  • Diane Green,

    Affiliation: CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia

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  • Timothy J. Hancock,

    Affiliation: CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia

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  • Yee-Peng Chan,

    Affiliation: Department of Microbiology and Immunology, Uniformed Services University, Bethesda, Maryland, United States of America

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  • Andrew C. Hickey,

    Affiliation: Department of Microbiology and Immunology, Uniformed Services University, Bethesda, Maryland, United States of America

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  • Dimiter S. Dimitrov,

    Affiliation: Protein Interactions Group, CCRNP, CCR, NCI-Frederick, NIH, Frederick, Maryland, United States of America

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  • Lin-Fa Wang,

    Affiliation: CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia

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  • Christopher C. Broder mail

    kbossart@bu.edu (KNB); cbroder@usuhs.mil (CCB)

    Affiliation: Department of Microbiology and Immunology, Uniformed Services University, Bethesda, Maryland, United States of America

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  • Published: October 30, 2009
  • DOI: 10.1371/journal.ppat.1000642

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Nipah model on TWiV

Posted by Profvrr on 01 Dec 2009 at 19:53 GMT

We discussed this paper on episode #58 of the podcast "This Week in Virology". Head on over to www.twiv.tv to check it out. In our discussion we explain the results of this study and their practical consequences in language accessible to the non-scientist.

No competing interests declared.