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Research Article

Mobile Genetic Element-Encoded Cytolysin Connects Virulence to Methicillin Resistance in MRSA

  • Shu Y. Queck,

    Affiliation: Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland, and Hamilton, Montana, United States of America

    Current address: Nanyang Polytechnic, Singapore

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  • Burhan A. Khan,

    Affiliation: Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland, and Hamilton, Montana, United States of America

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  • Rong Wang,

    Affiliation: Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland, and Hamilton, Montana, United States of America

    Current address: Laboratory of Intracellular Parasites, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Hamilton, Montana, United States of America

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  • Thanh-Huy L. Bach,

    Affiliation: Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland, and Hamilton, Montana, United States of America

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  • Dorothee Kretschmer,

    Affiliation: Cellular and Molecular Microbiology Unit, Medical Microbiology and Hygiene Department, University of Tübingen, Tübingen, Germany

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  • Liang Chen,

    Affiliation: Public Health Research Institute, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, United States of America

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  • Barry N. Kreiswirth,

    Affiliation: Public Health Research Institute, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, United States of America

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  • Andreas Peschel,

    Affiliation: Cellular and Molecular Microbiology Unit, Medical Microbiology and Hygiene Department, University of Tübingen, Tübingen, Germany

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  • Frank R. DeLeo,

    Affiliation: Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland, and Hamilton, Montana, United States of America

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  • Michael Otto mail

    motto@niaid.nih.gov

    Affiliation: Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland, and Hamilton, Montana, United States of America

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  • Published: July 31, 2009
  • DOI: 10.1371/journal.ppat.1000533

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Addition to Fig. 3 Legend

Posted by PLoS_Pathogens on 31 Jul 2009 at 17:25 GMT

Type II and III SCCmec elements are shown on the top, based on Genbank accession numbers D86934 (strain S. aureus N315, type II) and AB037671 (type III) [14]. The essential mec (methicillin resistance and regulation) and ccr (recombinase) genes are shown in color, other accessory elements are in grey. The region that contains the psm-mec gene and the overlapping fudoh locus [39] is magnified at the bottom. SD, Shine-Dalgarno sequence.
http://plospathogens.org/article/info:doi/10.1371/journal.ppat.1000533#ppat-1000533-g003

In Figure 3, the DNA fragment containing fudoh and psm-mec at the bottom is reversed relative to the SCCmec element at the top, to show translation of the psm-mec gene

No competing interests declared.