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Research Article

Real-Time High Resolution 3D Imaging of the Lyme Disease Spirochete Adhering to and Escaping from the Vasculature of a Living Host

  • Tara J. Moriarty equal contributor,

    equal contributor Contributed equally to this work with: Tara J. Moriarty, M. Ursula Norman

    Affiliations: Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada, Department of Microbiology & Infectious Diseases, University of Calgary, Calgary, Alberta, Canada

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  • M. Ursula Norman equal contributor,

    equal contributor Contributed equally to this work with: Tara J. Moriarty, M. Ursula Norman

    Affiliation: Department of Physiology & Biophysics, University of Calgary, Calgary, Alberta, Canada

    Current address: Centre for Inflammatory Diseases, Department of Medicine, Monash University, Victoria, Australia

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  • Pina Colarusso,

    Affiliation: Department of Physiology & Biophysics, University of Calgary, Calgary, Alberta, Canada

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  • Troy Bankhead,

    Affiliations: Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada, Department of Microbiology & Infectious Diseases, University of Calgary, Calgary, Alberta, Canada

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  • Paul Kubes,

    Affiliation: Department of Physiology & Biophysics, University of Calgary, Calgary, Alberta, Canada

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  • George Chaconas mail

    chaconas@ucalgary.ca

    Affiliations: Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada, Department of Microbiology & Infectious Diseases, University of Calgary, Calgary, Alberta, Canada

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  • Published: June 20, 2008
  • DOI: 10.1371/journal.ppat.1000090

Reader Comments (1)

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Well thought out and well executed

Posted by DavidWaldock on 20 Jun 2008 at 15:09 GMT

This stunning experiment quite literally changes the way we think about and visualise spirochaetes and how they interact with their hosts. Well conceptualised, and using contributions from various technical experts, this sets the standard for direct observation of pathogens in vivo.