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Research Article

A Novel Rhabdovirus Associated with Acute Hemorrhagic Fever in Central Africa

  • Gilda Grard equal contributor,

    equal contributor Contributed equally to this work with: Gilda Grard, Joseph N. Fair, Deanna Lee

    Affiliations: Viral Emergent Diseases unit, Centre International de Recherches Médicales de Franceville, Franceville, Gabon, MIVEGEC, UMR (IRD 224 - CNRS 5290 - UM1 - UM2), Institut de Recherche pour le Développement, Montpellier, France

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  • Joseph N. Fair equal contributor,

    equal contributor Contributed equally to this work with: Gilda Grard, Joseph N. Fair, Deanna Lee

    Affiliation: Global Viral Forecasting, Incorporated, San Francisco, California, United States of America

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  • Deanna Lee equal contributor,

    equal contributor Contributed equally to this work with: Gilda Grard, Joseph N. Fair, Deanna Lee

    Affiliations: Department of Laboratory Medicine, University of California, San Francisco, California, United States of America, UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, California, United States of America

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  • Elizabeth Slikas,

    Affiliation: Blood Systems Research Institute, San Francisco, California, United States of America

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  • Imke Steffen,

    Affiliation: Blood Systems Research Institute, San Francisco, California, United States of America

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  • Jean-Jacques Muyembe,

    Affiliation: Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo

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  • Taylor Sittler,

    Affiliations: Department of Laboratory Medicine, University of California, San Francisco, California, United States of America, UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, California, United States of America

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  • Narayanan Veeraraghavan,

    Affiliations: Department of Laboratory Medicine, University of California, San Francisco, California, United States of America, UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, California, United States of America

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  • J. Graham Ruby,

    Affiliations: Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America, Department of Biochemistry, University of California, San Francisco, California, United States of America

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  • Chunlin Wang,

    Affiliation: Department of Biochemistry, Stanford University, Stanford, California, United States of America

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  • Maria Makuwa,

    Affiliation: Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo

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  • Prime Mulembakani,

    Affiliation: Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo

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  • Robert B. Tesh,

    Affiliation: Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Jonna Mazet,

    Affiliation: Department of Epidemiology, University of California at Davis, Davis, California, United States of America

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  • Anne W. Rimoin,

    Affiliation: Department of Epidemiology, University of California at Los Angeles, Los Angeles, California, United States of America

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  • Travis Taylor,

    Affiliation: Global Viral Forecasting, Incorporated, San Francisco, California, United States of America

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  • Bradley S. Schneider,

    Affiliation: Global Viral Forecasting, Incorporated, San Francisco, California, United States of America

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  • Graham Simmons,

    Affiliation: Blood Systems Research Institute, San Francisco, California, United States of America

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  • Eric Delwart,

    Affiliation: Blood Systems Research Institute, San Francisco, California, United States of America

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  • Nathan D. Wolfe,

    Affiliation: Global Viral Forecasting, Incorporated, San Francisco, California, United States of America

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  • Charles Y. Chiu mail,

    charles.chiu@ucsf.edu (CYC); eric.leroy@ird.fr (EML)

    Affiliations: Department of Laboratory Medicine, University of California, San Francisco, California, United States of America, UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, California, United States of America, Department of Medicine, Division of Infectious Diseases, University of California, San Francisco, San Francisco, California, United States of America

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  • Eric M. Leroy mail

    charles.chiu@ucsf.edu (CYC); eric.leroy@ird.fr (EML)

    Affiliations: Viral Emergent Diseases unit, Centre International de Recherches Médicales de Franceville, Franceville, Gabon, MIVEGEC, UMR (IRD 224 - CNRS 5290 - UM1 - UM2), Institut de Recherche pour le Développement, Montpellier, France

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  • Published: September 27, 2012
  • DOI: 10.1371/journal.ppat.1002924

Reader Comments (2)

Post a new comment on this article

Confounding?..

Posted by madbat on 29 Nov 2012 at 16:42 GMT

The paper is interesting, and the virus is novel. The only sure thing.

To me, at this point there are too many speculations and conjectures regarding association of this virus with the disease outbreak. Still can be a confounding. As authors fairly mentioned, there are still quite many cases of VHS with unknown etiology (and negative for this novel virus).

Too pity that the virus could not be isolated (perhaps because of the VNA presence?) and characterized more rigorously.

More doubts on the Di-Ma transmission, possible vectors etc...

I would prefer to see more fair and unbiased discussion.

No competing interests declared.

RE: Confounding?..

cychiu98 replied to madbat on 29 Nov 2012 at 20:13 GMT

Efforts are underway in central Africa to track down the origin of this virus. We are also working on generation of infectious virus directly from cloned cDNA, as described previously for other rhabdoviruses such as rabies (Schnell, et al., 1994, EMBO J 13(18):4195-203), which will permit more rigorous characterization.

No competing interests declared.