Advertisement
Research Article

Convergence and Divergence in the Evolution of the APOBEC3G-Vif Interaction Reveal Ancient Origins of Simian Immunodeficiency Viruses

  • Alex A. Compton,

    Affiliations: Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, Washington, United States of America, Divisions of Human Biology and Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Michael Emerman mail

    memerman@fhcrc.org

    Affiliation: Divisions of Human Biology and Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Published: January 24, 2013
  • DOI: 10.1371/journal.ppat.1003135

Reader Comments (1)

Post a new comment on this article

selection pressure implies fitness cost of natural SIV infections

Posted by vmuller on 25 Jan 2013 at 19:26 GMT

SIV infections of natural host species are currently considered (largely) nonpathogenic. However, the new results presented here suggest that this group of viruses has imposed considerable and durable selection pressure for millions of years: this indicates that these infections must have some fitness cost after all.

No competing interests declared.