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Research Article

A Surface Groove Essential for Viral Bcl-2 Function During Chronic Infection In Vivo

  • Joy Loh equal contributor,

    equal contributor Contributed equally to this work with: Joy Loh, Qiulong Huang

    Affiliation: Departments of Pathology and Immunology and Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Qiulong Huang equal contributor,

    equal contributor Contributed equally to this work with: Joy Loh, Qiulong Huang

    Affiliation: Pharmaceutical Discovery Division, Abbott Laboratories, Abbott Park, Illinois, United States of America

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  • Andrew M Petros,

    Affiliation: Pharmaceutical Discovery Division, Abbott Laboratories, Abbott Park, Illinois, United States of America

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  • David Nettesheim,

    Affiliation: Pharmaceutical Discovery Division, Abbott Laboratories, Abbott Park, Illinois, United States of America

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  • Linda F. van Dyk,

    Affiliation: Department of Microbiology, University of Colorado Health Science Center, Aurora, Colorado, United States of America

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  • Lucia Labrada,

    Affiliation: Department of Medicine, Columbia College of Physicians and Surgeons, New York, New York, United States of America

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  • Samuel H Speck,

    Affiliation: Division of Microbiology and Immunology, Yerkes Regional Primate Center, Emory University, Atlanta, Georgia, United States of America

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  • Beth Levine,

    Affiliation: Departments of Internal Medicine and Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Edward T Olejniczak ,

    Affiliation: Pharmaceutical Discovery Division, Abbott Laboratories, Abbott Park, Illinois, United States of America

    These authors are joint senior authors on this work.

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  • Herbert W Virgin IV mail

    To whom correspondence should be addressed. E-mail: virgin@wustl.edu

    Affiliation: Departments of Pathology and Immunology and Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America

    These authors are joint senior authors on this work.

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  • Published: September 30, 2005
  • DOI: 10.1371/journal.ppat.0010010

About the Authors

Joy Loh, Herbert W Virgin IV
Departments of Pathology and Immunology and Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
Qiulong Huang, Andrew M Petros, David Nettesheim, Edward T Olejniczak
Pharmaceutical Discovery Division, Abbott Laboratories, Abbott Park, Illinois, United States of America
Linda F. van Dyk
Department of Microbiology, University of Colorado Health Science Center, Aurora, Colorado, United States of America
Lucia Labrada
Department of Medicine, Columbia College of Physicians and Surgeons, New York, New York, United States of America
Samuel H Speck
Division of Microbiology and Immunology, Yerkes Regional Primate Center, Emory University, Atlanta, Georgia, United States of America
Beth Levine
Departments of Internal Medicine and Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Corresponding Author

Email: virgin@wustl.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

All authors participated in conception and design of the experiments. JL, QH, LFvD, and LL performed the experiments. All authors participated in analysis of the data. JL, QH, BL, ETO, and HWV wrote the paper.