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Research Article

Increased Fidelity Reduces Poliovirus Fitness and Virulence under Selective Pressure in Mice

  • Julie K. Pfeiffer,

    Affiliation: Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Karla Kirkegaard mail

    To whom correspondence should be addressed. E-mail: karlak@stanford.edu

    Affiliation: Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Published: October 07, 2005
  • DOI: 10.1371/journal.ppat.0010011

About the Authors

Julie K. Pfeiffer, Karla Kirkegaard
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America

Corresponding Author

Email: karlak@stanford.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JKP and KK conceived and designed the experiments. JKP performed the experiments. JKP and KK analyzed the data, and wrote the paper.