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Research Article

NOD2 and Toll-Like Receptors Are Nonredundant Recognition Systems of Mycobacterium tuberculosis

  • Gerben Ferwerda,

    Affiliations: Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands, Nijmegen University Center for Infectious Diseases, Nijmegen, The Netherlands

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  • Stephen E Girardin,

    Affiliation: Unité de Pathogénie Microbienne Moléculaire, INSERM U389, Institut Pasteur, Paris Cedex, France

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  • Bart-Jan Kullberg,

    Affiliations: Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands, Nijmegen University Center for Infectious Diseases, Nijmegen, The Netherlands

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  • Lionel Le Bourhis,

    Affiliation: Unité de Pathogénie Microbienne Moléculaire, INSERM U389, Institut Pasteur, Paris Cedex, France

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  • Dirk J. de Jong,

    Affiliation: Department of Gastroenterology, Radboud University Medical Center, Nijmegen, The Netherlands

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  • Dennis M. L Langenberg,

    Affiliation: Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands

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  • Reinout van Crevel,

    Affiliations: Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands, Nijmegen University Center for Infectious Diseases, Nijmegen, The Netherlands

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  • Gosse J Adema,

    Affiliation: Department of Tumor Immunology, Radboud University Medical Center, Nijmegen, The Netherlands

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  • Tom H. M Ottenhoff,

    Affiliation: Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands

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  • Jos W. M. Van der Meer,

    Affiliations: Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands, Nijmegen University Center for Infectious Diseases, Nijmegen, The Netherlands

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  • Mihai G Netea mail

    To whom correspondence should be addressed. E-mail: M.Netea@aig.umcn.nl

    Affiliations: Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands, Nijmegen University Center for Infectious Diseases, Nijmegen, The Netherlands

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  • Published: November 25, 2005
  • DOI: 10.1371/journal.ppat.0010034

About the Authors

Gerben Ferwerda, Bart-Jan Kullberg, Reinout van Crevel, Jos W. M. Van der Meer, Mihai G Netea
Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
Gerben Ferwerda, Bart-Jan Kullberg, Reinout van Crevel, Jos W. M. Van der Meer, Mihai G Netea
Nijmegen University Center for Infectious Diseases, Nijmegen, The Netherlands
Stephen E Girardin, Lionel Le Bourhis
Unité de Pathogénie Microbienne Moléculaire, INSERM U389, Institut Pasteur, Paris Cedex, France
Dirk J. de Jong
Department of Gastroenterology, Radboud University Medical Center, Nijmegen, The Netherlands
Dennis M. L Langenberg, Tom H. M Ottenhoff
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
Gosse J Adema
Department of Tumor Immunology, Radboud University Medical Center, Nijmegen, The Netherlands

Corresponding Author

Email: M.Netea@aig.umcn.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

GF, SEG, BK, THMO, JWMV, and MGN conceived and designed the experiments. SEG, LL, DJD, and DMLL performed the experiments. GF, SEG, RV, GJA, and MGN analyzed the data. LL, DJD, DMLL, RV, and THMO contributed reagents/materials/analysis tools. GF, SEG, BK, GJA, THMO, JWMV, and MGN wrote the paper.