Advertisement
Research Article

Using the TAP Component of the Antigen-Processing Machinery as a Molecular Adjuvant

  • Timothy Z Vitalis,

    Affiliations: The Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada, Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada, The Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Qian-Jin Zhang,

    Affiliations: The Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada, Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada, The Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada

    ¤a Current address: Cellular Biology and Anatomy, LSU Health Sciences Center, Shreveport, Louisiana, United States of America

    X
  • Judie Alimonti,

    Affiliations: The Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada, Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada, The Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada

    ¤b Current address: Manitoba Institute of Cell Biology, Winnipeg, Manitoba, Canada

    X
  • Susan S Chen,

    Affiliations: The Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada, Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada, Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada, The Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Genc Basha,

    Affiliations: The Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada, Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada, The Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Alex Moise,

    Affiliations: The Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada, Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada, Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada, The Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada

    ¤c Current address: Case Western Reserve University, Cleveland, Ohio, United States of America

    X
  • Jacqueline Tiong,

    Affiliations: The Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada, Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada, The Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Mei Mei Tian,

    Affiliations: The Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada, Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada, The Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Kyung Bok Choi,

    Affiliations: The Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada, Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada, The Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Douglas Waterfield,

    Affiliations: Department of Oral Biology, Faculty of Dentistry, University of British Columbia, Vancouver, British Columbia, Canada, The Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Andy Jeffries,

    Affiliations: The Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada, Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada, The Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Wilfred A Jefferies mail

    To whom correspondence should be addressed. E-mail: wilf@brc.ubc.ca

    Affiliations: The Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada, Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada, Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada, The Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Published: December 30, 2005
  • DOI: 10.1371/journal.ppat.0010036

About the Authors

Timothy Z Vitalis, Timothy Z Vitalis, Qian-Jin Zhang, Qian-Jin Zhang, Judie Alimonti, Judie Alimonti, Susan S Chen, Susan S Chen, Genc Basha, Genc Basha, Alex Moise, Alex Moise, Jacqueline Tiong, Jacqueline Tiong, Mei Mei Tian, Mei Mei Tian, Kyung Bok Choi, Kyung Bok Choi, Douglas Waterfield, Andy Jeffries, Andy Jeffries, Wilfred A Jefferies, Wilfred A Jefferies
The Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada
Timothy Z Vitalis, Qian-Jin Zhang, Judie Alimonti, Susan S Chen, Genc Basha, Alex Moise, Jacqueline Tiong, Mei Mei Tian, Kyung Bok Choi, Andy Jeffries, Wilfred A Jefferies
Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
Judie Alimonti, Jacqueline Tiong, Mei Mei Tian, Wilfred A Jefferies
Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
Susan S Chen, Alex Moise, Wilfred A Jefferies
Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada
Douglas Waterfield
Department of Oral Biology, Faculty of Dentistry, University of British Columbia, Vancouver, British Columbia, Canada
Wilfred A Jefferies
Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada

Corresponding Author

Email: wilf@brc.ubc.ca

Competing Interests

The University of British Columbia and its scientists (TZV, QZ, JA, and WAJ) received equity in GeneMax as part of a technology license agreement between the University of British Columbia and GeneMax. WAJ is a director of GeneMax. GeneMax provided partial financial support for this study.

Author Contributions

WAJ conceived and designed the experiments. TZV, QZ, JA, SSC, GB, AM, JT, MMT, KBC, DW, and AJ performed the experiments. TZV and WAJ analyzed the data and wrote the paper.