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Research Article

The Beta-Glucan Receptor Dectin-1 Recognizes Specific Morphologies of Aspergillus fumigatus

  • Chad Steele mail,

    To whom correspondence should be addressed. E-mail: chad.steele@chp.edu

    Affiliation: Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

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  • Rekha R Rapaka,

    Affiliation: Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

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  • Allison Metz,

    Affiliation: Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

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  • Shannon M Pop,

    Affiliation: Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

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  • David L Williams,

    Affiliation: Department of Surgery, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, United States of America

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  • Siamon Gordon,

    Affiliation: Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom

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  • Jay K Kolls,

    Affiliation: Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

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  • Gordon D Brown

    Affiliation: Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa

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  • Published: December 09, 2005
  • DOI: 10.1371/journal.ppat.0010042

About the Authors

Chad Steele, Rekha R Rapaka, Allison Metz, Shannon M Pop, Jay K Kolls
Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
David L Williams
Department of Surgery, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, United States of America
Siamon Gordon
Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
Gordon D Brown
Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa

Corresponding Author

Email: chad.steele@chp.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

CS, RRR, AM, and SMP performed the experiments. CS, SMP, and GDB analyzed the data. CS, RRR, DLW, SG, JKK, and GDB contributed reagents/materials/analysis tools. CS conceived and designed the experiments, and wrote the paper.