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Research Article

Gene-Specific Countermeasures against Ebola Virus Based on Antisense Phosphorodiamidate Morpholino Oligomers

  • Kelly L Warfield equal contributor,

    equal contributor Contributed equally to this work with: Kelly L Warfield, Dana L Swenson

    Affiliation: US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, United States of America

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  • Dana L Swenson equal contributor,

    equal contributor Contributed equally to this work with: Kelly L Warfield, Dana L Swenson

    Affiliation: US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, United States of America

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  • Gene G Olinger,

    Affiliation: US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, United States of America

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  • Donald K Nichols,

    Affiliation: US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, United States of America

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  • William D Pratt,

    Affiliation: US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, United States of America

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  • Robert Blouch,

    Affiliation: AVI BioPharma, Corvallis, Oregon, United States of America

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  • David A Stein,

    Affiliation: AVI BioPharma, Corvallis, Oregon, United States of America

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  • M. Javad Aman,

    Affiliation: US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, United States of America

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  • Patrick L Iversen,

    Affiliation: AVI BioPharma, Corvallis, Oregon, United States of America

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  • Sina Bavari mail

    To whom correspondence should be addressed. E-mail: sina.bavari@amedd.army.mil

    Affiliation: US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, United States of America

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  • Published: January 13, 2006
  • DOI: 10.1371/journal.ppat.0020001

About the Authors

Kelly L Warfield, Dana L Swenson, Gene G Olinger, Donald K Nichols, William D Pratt, M. Javad Aman, Sina Bavari
US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, United States of America
Robert Blouch, David A Stein, Patrick L Iversen
AVI BioPharma, Corvallis, Oregon, United States of America

Corresponding Author

Email: sina.bavari@amedd.army.mil

Competing Interests

RB, DAS, and PLI have financial interest in AVI BioPharma, the company that supplied the PMO compounds for these studies.

Author Contributions

KLW, DLS, GGO, DKN, WDP, RB, DAS, PLI, and SB conceived and designed the experiments. KLW, DLS, GGO, DKN, WDP, RB, DAS, and SB performed the experiments. KLW, DLS, GGO, DKN, WDP, RB, DAS, MJA, PLI, and SB analyzed the data. PLI and SB contributed reagents/materials/analysis tools. KLW, MJA, DAS, and SB wrote the paper.