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Research Article

Genome-Wide Analysis of Group A Streptococci Reveals a Mutation That Modulates Global Phenotype and Disease Specificity

  • Paul Sumby,

    Affiliations: Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, Houston, Texas, United States of America, Center for Human Bacterial Pathogenesis Research, Department of Pathology, Baylor College of Medicine, Houston, Texas, United States of America

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  • Adeline R Whitney,

    Affiliation: Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

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  • Edward A Graviss,

    Affiliation: Center for Human Bacterial Pathogenesis Research, Department of Pathology, Baylor College of Medicine, Houston, Texas, United States of America

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  • Frank R DeLeo,

    Affiliation: Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

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  • James M Musser mail

    To whom correspondence should be addressed. E-mail: jmmusser@tmh.tmc.edu

    Affiliations: Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, Houston, Texas, United States of America, Center for Human Bacterial Pathogenesis Research, Department of Pathology, Baylor College of Medicine, Houston, Texas, United States of America

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  • Published: January 27, 2006
  • DOI: 10.1371/journal.ppat.0020005

About the Authors

Paul Sumby, James M Musser
Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, Houston, Texas, United States of America
Paul Sumby, Edward A Graviss, James M Musser
Center for Human Bacterial Pathogenesis Research, Department of Pathology, Baylor College of Medicine, Houston, Texas, United States of America
Adeline R Whitney, Frank R DeLeo
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

Corresponding Author

Email: jmmusser@tmh.tmc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

PS, FRD, and JMM conceived and designed the experiments. PS and ARW performed the experiments. PS, ARW, EAG, FRD, and JMM analyzed the data. PS and JMM wrote the paper.