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Research Article

Why Do HIV-1 and HIV-2 Use Different Pathways to Develop AZT Resistance?

  • Paul L Boyer,

    Affiliation: HIV Drug Resistance Program, NCI-Frederick, Frederick, Maryland, United States of America

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  • Stefan G Sarafianos,

    Affiliation: Center for Advanced Biotechnology and Medicine and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey, United States of America

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  • Patrick K Clark,

    Affiliation: Basic Research Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, United States of America

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  • Eddy Arnold,

    Affiliation: Center for Advanced Biotechnology and Medicine and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey, United States of America

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  • Stephen H Hughes mail

    To whom correspondence should be addressed. E-mail: hughes@ncifcrf.gov

    Affiliation: HIV Drug Resistance Program, NCI-Frederick, Frederick, Maryland, United States of America

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  • Published: February 17, 2006
  • DOI: 10.1371/journal.ppat.0020010

About the Authors

Paul L Boyer, Stephen H Hughes
HIV Drug Resistance Program, NCI-Frederick, Frederick, Maryland, United States of America
Stefan G Sarafianos, Eddy Arnold
Center for Advanced Biotechnology and Medicine and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey, United States of America
Patrick K Clark
Basic Research Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, United States of America

Corresponding Author

Email: hughes@ncifcrf.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

PLB, SGS, EA, and SHH conceived and designed the experiments. PLB and SGS performed the experiments. PLB, SGS, EA, and SHH analyzed the data. PKC purified the wild-type and mutant RTs used in the experiments. PLB, SGS, and PKC contributed reagents/materials/analysis tools. PLB, SGS, EA, and SHH wrote the paper.