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Research Article

Identification of a Novel Gammaretrovirus in Prostate Tumors of Patients Homozygous for R462Q RNASEL Variant

  • Anatoly Urisman equal contributor,

    equal contributor Contributed equally to this work with: Anatoly Urisman, Ross J Molinaro, Nicole Fischer

    Affiliation: Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America

    X
  • Ross J Molinaro equal contributor,

    equal contributor Contributed equally to this work with: Anatoly Urisman, Ross J Molinaro, Nicole Fischer

    Affiliations: Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America, Department of Chemistry, Cleveland State University, Cleveland, Ohio, United States of America

    X
  • Nicole Fischer equal contributor,

    equal contributor Contributed equally to this work with: Anatoly Urisman, Ross J Molinaro, Nicole Fischer

    Affiliation: Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America

    X
  • Sarah J Plummer,

    Affiliation: Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

    X
  • Graham Casey,

    Affiliation: Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

    X
  • Eric A Klein,

    Affiliation: Glickman Urological Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

    X
  • Krishnamurthy Malathi,

    Affiliation: Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

    X
  • Cristina Magi-Galluzzi,

    Affiliation: Anatomic and Clinical Pathology, Cleveland Clinic, Cleveland, Ohio, United States of America

    X
  • Raymond R Tubbs,

    Affiliation: Anatomic and Clinical Pathology, Cleveland Clinic, Cleveland, Ohio, United States of America

    X
  • Don Ganem,

    Affiliations: Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California, United States of America

    X
  • Robert H Silverman mail,

    To whom correspondence should be addressed. E-mail: joe@derisilab.ucsf.edu (JLD); silverr@ccf.org (RHS)

    Affiliation: Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

    X
  • Joseph L DeRisi mail

    To whom correspondence should be addressed. E-mail: joe@derisilab.ucsf.edu (JLD); silverr@ccf.org (RHS)

    Affiliations: Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California, United States of America

    X
  • Published: March 31, 2006
  • DOI: 10.1371/journal.ppat.0020025

About the Authors

Anatoly Urisman, Joseph L DeRisi
Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
Ross J Molinaro, Sarah J Plummer, Graham Casey, Krishnamurthy Malathi, Robert H Silverman
Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
Ross J Molinaro
Department of Chemistry, Cleveland State University, Cleveland, Ohio, United States of America
Nicole Fischer, Don Ganem
Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America
Eric A Klein
Glickman Urological Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
Cristina Magi-Galluzzi, Raymond R Tubbs
Anatomic and Clinical Pathology, Cleveland Clinic, Cleveland, Ohio, United States of America
Don Ganem
Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
Don Ganem, Joseph L DeRisi
Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

AU, RJM, NF, DG, RHS, and JLD conceived and designed the experiments. AU, RJM, NF, SJP, KM, CMG, and RRT performed the experiments. AU, RJM, NF, SJP, GC, EAK, KM, CMG, RRT, DG, RHS, and JLD analyzed the data. AU, RJM, NF, SJP, GC, EAK, DG, RHS, and JLD contributed reagents/materials/analysis tools. AU, RJM, NF, DG, RHS, and JLD wrote the paper.