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Research Article

Anopheles gambiae Immune Responses to Human and Rodent Plasmodium Parasite Species

  • Yuemei Dong,

    Affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States

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  • Ruth Aguilar,

    Affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States

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  • Zhiyong Xi,

    Affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States

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  • Emma Warr,

    Affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States

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  • Emmanuel Mongin,

    Affiliations: Department of Human Genetics and Genome Quebec Innovation Centre, McGill University, Montreal, Quebec, Canada, European Molecular Biology Laboratory, European Bioinformatics Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

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  • George Dimopoulos mail

    To whom correspondence should be addressed. E-mail: gdimopou@jhsph.edu

    Affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States

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  • Published: June 09, 2006
  • DOI: 10.1371/journal.ppat.0020052

About the Authors

Yuemei Dong, Ruth Aguilar, Zhiyong Xi, Emma Warr, George Dimopoulos
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States
Emmanuel Mongin
Department of Human Genetics and Genome Quebec Innovation Centre, McGill University, Montreal, Quebec, Canada
Emmanuel Mongin
European Molecular Biology Laboratory, European Bioinformatics Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

Corresponding Author

Email: gdimopou@jhsph.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

YD conducted Plasmodium and bacterial infection assays, RNAi assays, and real-time quantitative PCR assays. RA provided technical assistance with RNAi assays. EM predicted and annotated the Anopheles gambiae transcriptome from the available genome sequence as of September 2004. EW performed gene-silencing assays with GNBPB1. ZX performed bacteria infection gene expression assays. GD designed microarray oligonucleotide sequences and performed microarray hybridization assays and was mainly responsible for the experimental design.