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Research Article

Host-Specific Response to HCV Infection in the Chimeric SCID-beige/Alb-uPA Mouse Model: Role of the Innate Antiviral Immune Response

  • Kathie-Anne Walters equal contributor mail,

    equal contributor Contributed equally to this work with: Kathie-Anne Walters, Michael A Joyce

    To whom correspondence should be addressed. E-mail: kathiw@u.washington.edu

    Affiliation: Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, United States of America

    X
  • Michael A Joyce equal contributor,

    equal contributor Contributed equally to this work with: Kathie-Anne Walters, Michael A Joyce

    Affiliation: Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada

    X
  • Jill C Thompson,

    Affiliation: Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, United States of America

    X
  • Maria W Smith,

    Affiliation: Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, United States of America

    X
  • Matthew M Yeh,

    Affiliation: Department of Pathology, School of Medicine, University of Washington, Seattle, Washington, United States of America

    X
  • Sean Proll,

    Affiliation: Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, United States of America

    X
  • Lin-Fu Zhu,

    Affiliation: Department of Surgery, University of Alberta, Edmonton, Alberta, Canada

    X
  • T. J Gao,

    Affiliation: Department of Surgery, University of Alberta, Edmonton, Alberta, Canada

    X
  • Norman M Kneteman,

    Affiliation: Department of Surgery, University of Alberta, Edmonton, Alberta, Canada

    X
  • D. Lorne Tyrrell,

    Affiliation: Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada

    X
  • Michael G Katze

    Affiliation: Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, United States of America

    X
  • Published: June 23, 2006
  • DOI: 10.1371/journal.ppat.0020059

About the Authors

Kathie-Anne Walters, Jill C Thompson, Maria W Smith, Sean Proll, Michael G Katze
Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, United States of America
Michael A Joyce, D. Lorne Tyrrell
Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada
Matthew M Yeh
Department of Pathology, School of Medicine, University of Washington, Seattle, Washington, United States of America
Lin-Fu Zhu, T. J Gao, Norman M Kneteman
Department of Surgery, University of Alberta, Edmonton, Alberta, Canada

Corresponding Author

Email: kathiw@u.washington.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

KAW, MAJ, MWS, and MGK conceived and designed the experiments. KAW, MAJ, JCT, LFZ, and TJG performed the experiments. KAW and MMY analyzed the data. KAW, MAJ, SP, LFZ, NMK, DLT, and MGK contributed reagents/materials/analysis tools. KAW and MGK wrote the paper.