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Research Article

Critical Role of Bcr1-Dependent Adhesins in C. albicans Biofilm Formation In Vitro and In Vivo

  • Clarissa J Nobile,

    Affiliations: Department of Microbiology, Columbia University, New York, New York, United States of America, Biological Sciences Program, Department of Biological Sciences, Columbia University, New York, New York, United States of America

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  • David R Andes,

    Affiliation: Department of Medicine, Section of Infectious Diseases, University of Wisconsin, Madison, Wisconsin, United States of America

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  • Jeniel E Nett,

    Affiliation: Department of Medicine, Section of Infectious Diseases, University of Wisconsin, Madison, Wisconsin, United States of America

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  • Frank J Smith Jr.,

    Affiliation: Department of Microbiology, Columbia University, New York, New York, United States of America

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  • Fu Yue,

    Affiliation: Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America

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  • Quynh-Trang Phan,

    Affiliation: Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America

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  • John E Edwards Jr.,

    Affiliations: Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America, The David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Scott G Filler,

    Affiliations: Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America, The David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Aaron P Mitchell mail

    To whom correspondence should be addressed. E-mail: apm4@columbia.edu

    Affiliation: Department of Microbiology, Columbia University, New York, New York, United States of America

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  • Published: July 07, 2006
  • DOI: 10.1371/journal.ppat.0020063

About the Authors

Clarissa J Nobile, Frank J Smith Jr., Aaron P Mitchell
Department of Microbiology, Columbia University, New York, New York, United States of America
Clarissa J Nobile
Biological Sciences Program, Department of Biological Sciences, Columbia University, New York, New York, United States of America
David R Andes, Jeniel E Nett
Department of Medicine, Section of Infectious Diseases, University of Wisconsin, Madison, Wisconsin, United States of America
Fu Yue, Quynh-Trang Phan, John E Edwards Jr., Scott G Filler
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America
John E Edwards Jr., Scott G Filler
The David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

Corresponding Author

Email: apm4@columbia.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

CJN, DRA, JEN, SGF, and APM conceived and designed the experiments. CJN, DRA, JEN, and QTP performed the experiments. CJN, DRA, JEN, JEE, SGF, and APM analyzed the data. FJS, FY, QTP, JEE, and SGF contributed reagents/materials/analysis tools. CJN, DRA, JEE, SGF, and APM wrote the paper.