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Research Article

DC-SIGN on B Lymphocytes Is Required For Transmission of HIV-1 to T Lymphocytes

  • Giovanna Rappocciolo mail,

    To whom correspondence should be addressed. E-mail: giovanna@pitt.edu

    Affiliation: Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Paolo Piazza,

    Affiliation: Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Craig L Fuller,

    Affiliation: Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    ¤ Current address: School of Health Sciences, Eastern Michigan University, Ypsilanti, Michigan, United States of America

    X
  • Todd A Reinhart,

    Affiliation: Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Simon C Watkins,

    Affiliation: Department of Cell Biology and Physiology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • David T Rowe,

    Affiliation: Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Mariel Jais,

    Affiliation: Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Phalguni Gupta,

    Affiliations: Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Charles R Rinaldo Jr.

    Affiliations: Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Published: July 14, 2006
  • DOI: 10.1371/journal.ppat.0020070

About the Authors

Giovanna Rappocciolo, Paolo Piazza, Craig L Fuller, Todd A Reinhart, David T Rowe, Mariel Jais, Phalguni Gupta, Charles R Rinaldo Jr.
Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
Simon C Watkins
Department of Cell Biology and Physiology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
Phalguni Gupta, Charles R Rinaldo Jr.
Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Corresponding Author

Email: giovanna@pitt.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

GR and CRR conceived and designed the experiments. GR, PP, CLF, and MJ performed the experiments. TAR, SCW, DTR, and PG contributed reagents/materials/analysis tools. GR and CRR analyzed the data and wrote the paper.