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Research Article

CD8+ T-Cell Responses to Trypanosoma cruzi Are Highly Focused on Strain-Variant trans-Sialidase Epitopes

  • Diana L Martin,

    Affiliation: Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America

    X
  • D. Brent Weatherly,

    Affiliation: Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America

    X
  • Susana A Laucella,

    Affiliation: Instituto Nacional de Parasiologia Dr. Mario Fatala Chaben/Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS/Malbran), Buenos Aires, Argentina

    X
  • Melissa A Cabinian,

    Affiliation: Department of Microbiology, University of Georgia, Athens, Georgia, United States of America

    X
  • Matthew T Crim,

    Affiliation: Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America

    X
  • Susan Sullivan,

    Affiliation: Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America

    ¤ Current address: Department of Biological Sciences, Louisiana State University at Alexandria, Alexandria, Louisiana, United States of America

    X
  • Mark Heiges,

    Affiliation: Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America

    X
  • Sarah H Craven,

    Affiliation: Department of Microbiology, University of Georgia, Athens, Georgia, United States of America

    X
  • Charles S Rosenberg,

    Affiliations: Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America, Department of Microbiology, University of Georgia, Athens, Georgia, United States of America

    X
  • Matthew H Collins,

    Affiliation: Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America

    X
  • Alessandro Sette,

    Affiliation: La Jolla Institute for Allergy and Immunology, San Diego, California, United States of America

    X
  • Miriam Postan,

    Affiliation: Instituto Nacional de Parasiologia Dr. Mario Fatala Chaben/Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS/Malbran), Buenos Aires, Argentina

    X
  • Rick L Tarleton mail

    To whom correspondence should be addressed. E-mail: tarleton@cb.uga.edu

    Affiliations: Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America, Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America

    X
  • Published: August 04, 2006
  • DOI: 10.1371/journal.ppat.0020077

About the Authors

Diana L Martin, D. Brent Weatherly, Mark Heiges, Charles S Rosenberg, Rick L Tarleton
Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America
Susana A Laucella, Miriam Postan
Instituto Nacional de Parasiologia Dr. Mario Fatala Chaben/Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS/Malbran), Buenos Aires, Argentina
Melissa A Cabinian, Sarah H Craven, Charles S Rosenberg
Department of Microbiology, University of Georgia, Athens, Georgia, United States of America
Matthew T Crim, Susan Sullivan, Matthew H Collins, Rick L Tarleton
Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America
Alessandro Sette
La Jolla Institute for Allergy and Immunology, San Diego, California, United States of America

Corresponding Author

Email: tarleton@cb.uga.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

DLM conducted the murine experiments except where noted. DBW performed the bioinformatics for all studies. SAL and MP performed the human studies and studies on the HLA-A2 transgenic mice (Figure S2). SS and MH carried out the initial identification of ts epitopes (Table S1). MAC, SHC, CSR, and MHC provided experimental data for Tables S1 and S2. MTC did initial in vivo cytotoxic T lymphocyte studies of ts epitopes (Figure 1B). AS determined the HLA-A2–binding affinities of peptides and predicted the H-2Kb–binding affinities of peptides. RLT provided the financial and intellectual support for all studies.