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Research Article

Doxycycline Reduces Plasma VEGF-C/sVEGFR-3 and Improves Pathology in Lymphatic Filariasis

  • Alexander Yaw Debrah equal contributor,

    equal contributor Contributed equally to this work with: Alexander Yaw Debrah, Sabine Mand

    Affiliations: Institute for Medical Microbiology, Immunology, and Parasitology, University of Bonn, Bonn, Germany, Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana, Department of Theoretical and Applied Biology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

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  • Sabine Mand equal contributor,

    equal contributor Contributed equally to this work with: Alexander Yaw Debrah, Sabine Mand

    Affiliation: Institute for Medical Microbiology, Immunology, and Parasitology, University of Bonn, Bonn, Germany

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  • Sabine Specht,

    Affiliation: Institute for Medical Microbiology, Immunology, and Parasitology, University of Bonn, Bonn, Germany

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  • Yeboah Marfo-Debrekyei,

    Affiliation: Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana

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  • Linda Batsa,

    Affiliation: Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana

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  • Kenneth Pfarr,

    Affiliation: Institute for Medical Microbiology, Immunology, and Parasitology, University of Bonn, Bonn, Germany

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  • John Larbi,

    Affiliation: Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana

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  • Bernard Lawson,

    Affiliation: Department of Theoretical and Applied Biology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

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  • Mark Taylor,

    Affiliation: Liverpool School of Tropical Medicine, Liverpool, United Kingdom

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  • Ohene Adjei,

    Affiliations: Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

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  • Achim Hoerauf mail

    To whom correspondence should be addressed. E-mail: hoerauf@parasit.meb.uni-bonn.de

    Affiliation: Institute for Medical Microbiology, Immunology, and Parasitology, University of Bonn, Bonn, Germany

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  • Published: September 15, 2006
  • DOI: 10.1371/journal.ppat.0020092

About the Authors

Alexander Yaw Debrah, Sabine Mand, Sabine Specht, Kenneth Pfarr, Achim Hoerauf
Institute for Medical Microbiology, Immunology, and Parasitology, University of Bonn, Bonn, Germany
Alexander Yaw Debrah, Yeboah Marfo-Debrekyei, Linda Batsa, John Larbi, Ohene Adjei
Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana
Alexander Yaw Debrah, Bernard Lawson
Department of Theoretical and Applied Biology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
Mark Taylor
Liverpool School of Tropical Medicine, Liverpool, United Kingdom
Ohene Adjei
School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

Corresponding Author

Email: hoerauf@parasit.meb.uni-bonn.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

AH, MT, and OA conceived and designed the experiments. AYD, SM, SS, YMD, LB, KP, and JL performed the experiments. AYD, SM, BL, and AH analyzed the data. AYD, SM, and AH wrote the paper.