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Research Article

Potent Nonnucleoside Reverse Transcriptase Inhibitors Target HIV-1 Gag-Pol

  • Anna Figueiredo,

    Affiliations: Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia, Department of Microbiology, Monash University, Clayton, Australia

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  • Katie L Moore,

    Affiliation: Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia

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  • Johnson Mak,

    Affiliations: HIV Assembly Group, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia

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  • Nicolas Sluis-Cremer,

    Affiliation: Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

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  • Marie-Pierre de Bethune,

    Affiliation: Tibotec Pharmaceuticals, Mechelen, Belgium

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  • Gilda Tachedjian mail

    To whom correspondence should be addressed. E-mail: gildat@burnet.edu.au

    Affiliations: Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia, Department of Microbiology, Monash University, Clayton, Australia, Department of Medicine, Monash University, Prahran, Australia

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  • Published: November 10, 2006
  • DOI: 10.1371/journal.ppat.0020119

About the Authors

Anna Figueiredo, Katie L Moore, Gilda Tachedjian
Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia
Anna Figueiredo, Gilda Tachedjian
Department of Microbiology, Monash University, Clayton, Australia
Johnson Mak
HIV Assembly Group, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia
Johnson Mak
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
Nicolas Sluis-Cremer
Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
Marie-Pierre de Bethune
Tibotec Pharmaceuticals, Mechelen, Belgium
Gilda Tachedjian
Department of Medicine, Monash University, Prahran, Australia

Corresponding Author

Email: gildat@burnet.edu.au

Competing Interests

Marie-Pierre de Bethune is an employee of Tibotec Pharmaceuticals, which provided TMC120 and TMC125.

Author Contributions

AF and GT conceived and designed the experiments. AF and KLM performed the experiments. AF and GT analyzed the data. JM, NSC, and MPdB contributed reagents/materials/analysis tools. AF, NSC, and GT wrote the paper.