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Research Article

Fz2 and Cdc42 Mediate Melanization and Actin Polymerization but Are Dispensable for Plasmodium Killing in the Mosquito Midgut

  • Shin-Hong Shiao equal contributor,

    equal contributor Contributed equally to this work with: Shin-Hong Shiao, Miranda M. A Whitten

    Affiliation: Institut de Biologie Moléculaire et Cellulaire, UPR9022 du CNRS, Équipe “Avenir” INSERM, Strasbourg, France

    ¤ Current address: Department of Entomology, University of California Riverside, Riverside, California, United States of America

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  • Miranda M. A Whitten equal contributor,

    equal contributor Contributed equally to this work with: Shin-Hong Shiao, Miranda M. A Whitten

    Affiliation: Institut de Biologie Moléculaire et Cellulaire, UPR9022 du CNRS, Équipe “Avenir” INSERM, Strasbourg, France

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  • Daniel Zachary,

    Affiliation: Institut de Biologie Moléculaire et Cellulaire, UPR9022 du CNRS, Équipe “Avenir” INSERM, Strasbourg, France

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  • Jules A Hoffmann,

    Affiliation: Institut de Biologie Moléculaire et Cellulaire, UPR9022 du CNRS, Équipe “Avenir” INSERM, Strasbourg, France

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  • Elena A Levashina mail

    To whom correspondence should be addressed. E-mail: e.levashina@ibmc.u-strasbg.fr

    Affiliation: Institut de Biologie Moléculaire et Cellulaire, UPR9022 du CNRS, Équipe “Avenir” INSERM, Strasbourg, France

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  • Published: December 29, 2006
  • DOI: 10.1371/journal.ppat.0020133

About the Authors

Shin-Hong Shiao, Miranda M. A Whitten, Daniel Zachary, Jules A Hoffmann, Elena A Levashina
Institut de Biologie Moléculaire et Cellulaire, UPR9022 du CNRS, Équipe “Avenir” INSERM, Strasbourg, France

Corresponding Author

Email: e.levashina@ibmc.u-strasbg.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

SHS and EAL conceived and designed the experiments. SHS and MMAW performed the experiments. SHS, MMAW, and DZ analyzed the data. DZ and EAL contributed reagents/materials/analysis tools. MMAW, JAH, and EAL wrote the paper.