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Research Article

Delayed Goblet Cell Hyperplasia, Acetylcholine Receptor Expression, and Worm Expulsion in SMC-Specific IL-4Rα–Deficient Mice

  • William G. C Horsnell,

    Affiliation: Division of Immunology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

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  • Antony J Cutler,

    Affiliation: Division of Immunology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

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  • Claire J Hoving,

    Affiliation: Division of Immunology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

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  • Helen Mearns,

    Affiliation: Division of Immunology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

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  • Elmarie Myburgh,

    Affiliation: Division of Immunology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

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  • Berenice Arendse,

    Affiliation: Division of Immunology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

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  • Fred D Finkelman,

    Affiliation: Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

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  • Gary K Owens,

    Affiliation: Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, Charlottesville, Virginia, United States of America

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  • Dave Erle,

    Affiliation: Lung Biology Center, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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  • Frank Brombacher mail

    To whom correspondence should be addressed. E-mail: fbrombac@uctgsh1.uct.ac.za

    Affiliation: Division of Immunology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

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  • Published: January 12, 2007
  • DOI: 10.1371/journal.ppat.0030001

About the Authors

William G. C Horsnell, Antony J Cutler, Claire J Hoving, Helen Mearns, Elmarie Myburgh, Berenice Arendse, Frank Brombacher
Division of Immunology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Fred D Finkelman
Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
Gary K Owens
Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, Charlottesville, Virginia, United States of America
Dave Erle
Lung Biology Center, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

Corresponding Author

Email: fbrombac@uctgsh1.uct.ac.za

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

WGCH and FB conceived and designed the experiments. WGCH, AJC, CJH, HM, EM, and BA performed the experiments. WGCH, AJC, and CJH analyzed the data. FDF, GKO, and DE contributed reagents/materials/analysis tools. WGCH and AJC wrote the paper.