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Research Article

Essential Gene Identification and Drug Target Prioritization in Aspergillus fumigatus

  • Wenqi Hu,

    Affiliation: Merck Frosst Center of Fungal Genetics, Montreal, Quebec, Canada

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  • Susan Sillaots,

    Affiliation: Merck Frosst Center of Fungal Genetics, Montreal, Quebec, Canada

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  • Sebastien Lemieux,

    Affiliation: Merck Frosst Center of Fungal Genetics, Montreal, Quebec, Canada

    ¤ Current address: Institute of Research in Immunology and Cancer, Université de Montréal, Montreal, Quebec, Canada

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  • John Davison,

    Affiliation: Merck Frosst Center of Fungal Genetics, Montreal, Quebec, Canada

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  • Sarah Kauffman,

    Affiliation: Department of Microbiology, University of Tennessee, Knoxville, Tennessee, United States of America

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  • Anouk Breton,

    Affiliation: Merck Frosst Center of Fungal Genetics, Montreal, Quebec, Canada

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  • Annie Linteau,

    Affiliation: Merck Frosst Center of Fungal Genetics, Montreal, Quebec, Canada

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  • Chunlin Xin,

    Affiliation: Merck Frosst Center of Fungal Genetics, Montreal, Quebec, Canada

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  • Joel Bowman,

    Affiliation: Infectious Diseases, Merck Research Laboratories, Rahway, New Jersey, United States of America

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  • Jeff Becker,

    Affiliation: Department of Microbiology, University of Tennessee, Knoxville, Tennessee, United States of America

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  • Bo Jiang,

    Affiliation: Merck Frosst Center of Fungal Genetics, Montreal, Quebec, Canada

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  • Terry Roemer mail

    To whom correspondence should be addressed. E-mail: terry_roemer@merck.com

    Affiliation: Merck Frosst Center of Fungal Genetics, Montreal, Quebec, Canada

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  • Published: March 09, 2007
  • DOI: 10.1371/journal.ppat.0030024

About the Authors

Wenqi Hu, Susan Sillaots, Sebastien Lemieux, John Davison, Anouk Breton, Annie Linteau, Chunlin Xin, Bo Jiang, Terry Roemer
Merck Frosst Center of Fungal Genetics, Montreal, Quebec, Canada
Sarah Kauffman, Jeff Becker
Department of Microbiology, University of Tennessee, Knoxville, Tennessee, United States of America
Joel Bowman
Infectious Diseases, Merck Research Laboratories, Rahway, New Jersey, United States of America

Corresponding Author

Email: terry_roemer@merck.com

Competing Interests

W. Hu, S. Sillaots, S. Lemieux, J. Davison, A. Breton, A. Linteau, C. Xin, J. Bowman, B. Jiang, and T. Roemer are current or previous employees of Merck & Co., Inc. and Elitra Phamarceuticals Inc. S. Kauffman and J. Becker are consultants to Elitra Phamarceuticals Inc.

Author Contributions

W. Hu and T. Roemer conceived and designed the experiments and wrote the paper. W. Hu, S. Sillaots, J. Davison, S. Kauffman, A. Breton, A. Linteau, C. Xin, and J. Bowman performed the experiments. W. Hu, S. Lemieux, S. Kauffman, J. Bowman, J. Becker, B. Jiang, and T. Roemer analyzed the data. S. Lemieux, J. Becker, and B. Jiang contributed reagents/materials/analysis tools.