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Research Article

Mechanism of Ad5 Vaccine Immunity and Toxicity: Fiber Shaft Targeting of Dendritic Cells

  • Cheng Cheng equal contributor,

    equal contributor Contributed equally to this work with: Cheng Cheng, Jason G. D Gall

    Affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Jason G. D Gall equal contributor,

    equal contributor Contributed equally to this work with: Cheng Cheng, Jason G. D Gall

    Affiliation: GenVec, Incorporated, Gaithersburg, Maryland, United States of America

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  • Wing-pui Kong,

    Affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Rebecca L Sheets,

    Affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Phillip L Gomez,

    Affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • C. Richter King,

    Affiliation: GenVec, Incorporated, Gaithersburg, Maryland, United States of America

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  • Gary J Nabel mail

    To whom correspondence should be addressed. E-mail: gnabel@nih.gov

    Affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Published: February 23, 2007
  • DOI: 10.1371/journal.ppat.0030025

About the Authors

Cheng Cheng, Wing-pui Kong, Rebecca L Sheets, Phillip L Gomez, Gary J Nabel
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Jason G. D Gall, C. Richter King
GenVec, Incorporated, Gaithersburg, Maryland, United States of America

Corresponding Author

Email: gnabel@nih.gov

Competing Interests

The authors have submitted an intellectual property application based on findings reported in this study.

Author Contributions

CC, JGDG, and WK performed virologic and immunological studies in murine models and were involved in the design, planning, data analysis, and writing of the paper. RLS and PLG were involved in experimental design and data analysis. CRK and GJN were involved in the design, planning, data analysis, and writing of the paper.