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Research Article

LRP5 and LRP6 Are Not Required for Protective Antigen–Mediated Internalization or Lethality of Anthrax Lethal Toxin

  • John J Young equal contributor,

    equal contributor Contributed equally to this work with: John J Young, Jennifer L Bromberg-White

    Affiliation: Laboratory of Cancer and Developmental Cell Biology, Van Andel Research Institute, Grand Rapids, Michigan, United States of America

    X
  • Jennifer L Bromberg-White equal contributor,

    equal contributor Contributed equally to this work with: John J Young, Jennifer L Bromberg-White

    Affiliation: Laboratory of Cancer and Developmental Cell Biology, Van Andel Research Institute, Grand Rapids, Michigan, United States of America

    X
  • Cassandra Zylstra,

    Affiliation: Laboratory of Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, Michigan, United States of America

    X
  • Joseph T Church,

    Affiliation: Laboratory of Cancer and Developmental Cell Biology, Van Andel Research Institute, Grand Rapids, Michigan, United States of America

    X
  • Elissa Boguslawski,

    Affiliation: Laboratory of Cancer and Developmental Cell Biology, Van Andel Research Institute, Grand Rapids, Michigan, United States of America

    X
  • James H Resau,

    Affiliation: Laboratory of Analytical, Cellular, and Molecular Microscopy, Van Andel Research Institute, Grand Rapids, Michigan, United States of America

    X
  • Bart O Williams,

    Affiliation: Laboratory of Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, Michigan, United States of America

    X
  • Nicholas S Duesbery mail

    To whom correspondence should be addressed. E-mail: duesbery@vai.org

    Affiliation: Laboratory of Cancer and Developmental Cell Biology, Van Andel Research Institute, Grand Rapids, Michigan, United States of America

    X
  • Published: March 02, 2007
  • DOI: 10.1371/journal.ppat.0030027

About the Authors

John J Young, Jennifer L Bromberg-White, Joseph T Church, Elissa Boguslawski, Nicholas S Duesbery
Laboratory of Cancer and Developmental Cell Biology, Van Andel Research Institute, Grand Rapids, Michigan, United States of America
Cassandra Zylstra, Bart O Williams
Laboratory of Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, Michigan, United States of America
James H Resau
Laboratory of Analytical, Cellular, and Molecular Microscopy, Van Andel Research Institute, Grand Rapids, Michigan, United States of America

Corresponding Author

Email: duesbery@vai.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JJY, JLBW, BOW, and NSD conceived and designed the experiments and analyzed the data. JJY, JLBW, CZ, JTC, EB, JHR, and NSD performed the experiments. BOW contributed reagents/materials/analysis tools. NSD wrote the paper.