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Research Article

Dynorphin Activates Quorum Sensing Quinolone Signaling in Pseudomonas aeruginosa

  • Olga Zaborina,

    Affiliation: Department of Surgery, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, United States of America

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  • Francois Lepine,

    Affiliation: Institut National de la Recherche Scientifique (INRS)–Institut Armand-Frappier, Laval, Quebec, Canada

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  • Gaoping Xiao,

    Affiliation: Department of Surgery, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Vesta Valuckaite,

    Affiliation: Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, United States of America

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  • Yimei Chen,

    Affiliation: Department of Biochemistry and Molecular Biology, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, United States of America

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  • Terry Li,

    Affiliation: Department of Immunohistochemistry, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, United States of America

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  • Mae Ciancio,

    Affiliation: Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, United States of America

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  • Alex Zaborin,

    Affiliation: Department of Surgery, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, United States of America

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  • Elaine Petroff,

    Affiliation: Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, United States of America

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  • Jerrold R Turner,

    Affiliation: Department of Pathology, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, United States of America

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  • Laurence G Rahme,

    Affiliation: Department of Surgery, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Eugene Chang,

    Affiliation: Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, United States of America

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  • John C Alverdy mail

    To whom correspondence should be addressed. E-mail: jalverdy@surgery.bsd.uchicago.edu

    Affiliation: Department of Surgery, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, United States of America

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  • Published: March 16, 2007
  • DOI: 10.1371/journal.ppat.0030035

About the Authors

Olga Zaborina, Alex Zaborin, John C Alverdy
Department of Surgery, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, United States of America
Francois Lepine
Institut National de la Recherche Scientifique (INRS)–Institut Armand-Frappier, Laval, Quebec, Canada
Gaoping Xiao, Laurence G Rahme
Department of Surgery, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Vesta Valuckaite, Mae Ciancio, Elaine Petroff, Eugene Chang
Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, United States of America
Yimei Chen
Department of Biochemistry and Molecular Biology, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, United States of America
Terry Li
Department of Immunohistochemistry, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, United States of America
Jerrold R Turner
Department of Pathology, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, United States of America

Corresponding Author

Email: jalverdy@surgery.bsd.uchicago.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

OZ, TL, MC, AZ, EP, and JCA conceived and designed the experiments. OZ, FL, GX, VV, YC, TL, MC, AZ, EP, and JCA performed the experiments. OZ, FL, TL, MC, AZ, EP, JRT, LGR, and JCA analyzed the data. OZ, FL, GX, YC, EP, LGR, EC, and JCA contributed reagents/materials/analysis tools. OZ, LGR, EC, and JCA wrote the paper.