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Research Article

Molecular Basis for a Lack of Correlation between Viral Fitness and Cell Killing Capacity

  • Mónica Herrera,

    Affiliation: Centro de Biología Molecular “Severo Ochoa” (CSIC-UAM), Cantoblanco, Madrid, Spain

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  • Juan García-Arriaza,

    Affiliation: Centro de Biología Molecular “Severo Ochoa” (CSIC-UAM), Cantoblanco, Madrid, Spain

    ¤a Current address: Centro Nacional de Biotecnología (CSIC), Cantoblanco, Madrid, Spain

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  • Nonia Pariente,

    Affiliation: Centro de Biología Molecular “Severo Ochoa” (CSIC-UAM), Cantoblanco, Madrid, Spain

    ¤b Current address: Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles AIDS Institute, Los Angeles, California, United States of America

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  • Cristina Escarmís,

    Affiliation: Centro de Biología Molecular “Severo Ochoa” (CSIC-UAM), Cantoblanco, Madrid, Spain

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  • Esteban Domingo mail

    To whom correspondence should be addressed. E-mail: edomingo@cbm.uam.es

    Affiliation: Centro de Biología Molecular “Severo Ochoa” (CSIC-UAM), Cantoblanco, Madrid, Spain

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  • Published: April 13, 2007
  • DOI: 10.1371/journal.ppat.0030053

About the Authors

Mónica Herrera, Juan García-Arriaza, Nonia Pariente, Cristina Escarmís, Esteban Domingo
Centro de Biología Molecular “Severo Ochoa” (CSIC-UAM), Cantoblanco, Madrid, Spain

Corresponding Author

Email: edomingo@cbm.uam.es

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

MH, NP, CE, and ED conceived and designed the experiments. MH performed the experiments. MH, JGA, NP, CE, and ED analyzed the data. MH, JGA, NP, and CE contributed viruses, plasmids, materials, and information. MH and ED wrote the paper.