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Research Article

A Novel TLR4-Mediated Signaling Pathway Leading to IL-6 Responses in Human Bladder Epithelial Cells

  • Jeongmin Song,

    Affiliation: Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Matthew J Duncan,

    Affiliation: Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Guojie Li,

    Affiliation: Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Cheryl Chan,

    Affiliation: Program in Cell and Molecular Biology, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Richard Grady,

    Affiliation: Children's Hospital and Regional Medical Center, Seattle, Washington, United States of America

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  • Ann Stapleton,

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

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  • Soman N Abraham mail

    To whom correspondence should be addressed. E-mail: soman.abraham@duke.edu

    Affiliations: Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Immunology, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Published: April 27, 2007
  • DOI: 10.1371/journal.ppat.0030060

About the Authors

Jeongmin Song, Matthew J Duncan, Soman N Abraham
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America
Guojie Li, Soman N Abraham
Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America
Cheryl Chan
Program in Cell and Molecular Biology, Duke University Medical Center, Durham, North Carolina, United States of America
Richard Grady
Children's Hospital and Regional Medical Center, Seattle, Washington, United States of America
Ann Stapleton
Department of Microbiology, University of Washington, Seattle, Washington, United States of America
Soman N Abraham
Department of Immunology, Duke University Medical Center, Durham, North Carolina, United States of America

Corresponding Author

Email: soman.abraham@duke.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JS, MJD, and SNA conceived and designed the experiments. JS and CC performed the experiments. JS, MJD, and SNA analyzed the data. GL, RG, and AS contributed reagents/materials/analysis tools. JS and SNA wrote the paper.