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Research Article

Escape of HIV-1 from a Small Molecule CCR5 Inhibitor Is Not Associated with a Fitness Loss

  • Cleo G Anastassopoulou,

    Affiliation: Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America

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  • Andre J Marozsan,

    Affiliation: Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America

    ¤a Current address: Research and Development, Boehringer Ingelheim (Canada), Quebec, Canada

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  • Alexandre Matet,

    Affiliation: Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America

    ¤b Current address: Department of Biology, École Normale Supérieure, Paris, France

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  • Amy D Snyder,

    Affiliation: Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America

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  • Eric J Arts,

    Affiliation: Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America

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  • Shawn E Kuhmann mail,

    To whom correspondence should be addressed. E-mail: sek2003@med.cornell.edu (SEK); jpm2003@med.cornell.edu (JPM)

    Affiliation: Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America

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  • John P Moore mail

    To whom correspondence should be addressed. E-mail: sek2003@med.cornell.edu (SEK); jpm2003@med.cornell.edu (JPM)

    Affiliation: Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America

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  • Published: June 01, 2007
  • DOI: 10.1371/journal.ppat.0030079

About the Authors

Cleo G Anastassopoulou, Andre J Marozsan, Alexandre Matet, Amy D Snyder, Shawn E Kuhmann, John P Moore
Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America
Eric J Arts
Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

CGA, AJM, EJA, SEK, and JPM conceived and designed the experiments. CGA performed the experiments. CGA and SEK analyzed the data. AJM, AM, ADS, and SEK contributed reagents/materials/analysis tools. CGA, SEK, and JPM wrote the paper.