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Research Article

The OmpA-Like Protein Loa22 Is Essential for Leptospiral Virulence

  • Paula Ristow,

    Affiliations: Unité de Biologie des Spirochètes, Institut Pasteur, Paris, France, Instituto de Microbiologia Professor Paulo de Goes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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  • Pascale Bourhy,

    Affiliation: Unité de Biologie des Spirochètes, Institut Pasteur, Paris, France

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  • Flávia Weykamp da Cruz McBride,

    Affiliation: Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil

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  • Claudio Pereira Figueira,

    Affiliation: Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil

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  • Michel Huerre,

    Affiliation: Unité de Recherche et d'Expertise Histotechnologie et Pathologie, Institut Pasteur, Paris, France

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  • Patrick Ave,

    Affiliation: Unité de Recherche et d'Expertise Histotechnologie et Pathologie, Institut Pasteur, Paris, France

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  • Isabelle Saint Girons,

    Affiliation: Unité de Biologie des Spirochètes, Institut Pasteur, Paris, France

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  • Albert I Ko,

    Affiliations: Instituto de Microbiologia Professor Paulo de Goes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, Division of International Medicine and Infectious Disease, Weill Medical College of Cornell University, New York, New York, United States of America

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  • Mathieu Picardeau mail

    To whom correspondence should be addressed. E-mail: mpicard@pasteur.fr

    Affiliation: Unité de Biologie des Spirochètes, Institut Pasteur, Paris, France

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  • Published: July 13, 2007
  • DOI: 10.1371/journal.ppat.0030097

About the Authors

Paula Ristow, Pascale Bourhy, Isabelle Saint Girons, Mathieu Picardeau
Unité de Biologie des Spirochètes, Institut Pasteur, Paris, France
Paula Ristow, Albert I Ko
Instituto de Microbiologia Professor Paulo de Goes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
Flávia Weykamp da Cruz McBride, Claudio Pereira Figueira
Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil
Michel Huerre, Patrick Ave
Unité de Recherche et d'Expertise Histotechnologie et Pathologie, Institut Pasteur, Paris, France
Albert I Ko
Division of International Medicine and Infectious Disease, Weill Medical College of Cornell University, New York, New York, United States of America

Corresponding Author

Email: mpicard@pasteur.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

PR, PB, MH, ISG, AIK, and MP conceived and designed the experiments. PR, PB, FWdCM, CPF, PA, and MP performed the experiments. PR, AIK, and MP wrote the paper.