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Research Article

Molecular Basis of Resistance to Muramidase and Cationic Antimicrobial Peptide Activity of Lysozyme in Staphylococci

  • Silvia Herbert,

    Affiliation: Microbial Genetics Department, University of Tübingen, Tübingen, Germany

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  • Agnieszka Bera,

    Affiliation: Microbial Genetics Department, University of Tübingen, Tübingen, Germany

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  • Christiane Nerz,

    Affiliation: Microbial Genetics Department, University of Tübingen, Tübingen, Germany

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  • Dirk Kraus,

    Affiliation: Medical Microbiology and Hygiene Department, University of Tübingen, Tübingen, Germany

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  • Andreas Peschel,

    Affiliation: Medical Microbiology and Hygiene Department, University of Tübingen, Tübingen, Germany

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  • Christiane Goerke,

    Affiliation: Medical Microbiology and Hygiene Department, University of Tübingen, Tübingen, Germany

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  • Michael Meehl,

    Affiliation: Department of Microbiology, Dartmouth Medical School, Hanover, New Hampshire, United States of America

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  • Ambrose Cheung,

    Affiliation: Department of Microbiology, Dartmouth Medical School, Hanover, New Hampshire, United States of America

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  • Friedrich Götz mail

    To whom correspondence should be addressed. E-mail: friedrich.goetz@uni-tuebingen.de

    Affiliation: Microbial Genetics Department, University of Tübingen, Tübingen, Germany

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  • Published: July 27, 2007
  • DOI: 10.1371/journal.ppat.0030102

About the Authors

Silvia Herbert, Agnieszka Bera, Christiane Nerz, Friedrich Götz
Microbial Genetics Department, University of Tübingen, Tübingen, Germany
Dirk Kraus, Andreas Peschel, Christiane Goerke
Medical Microbiology and Hygiene Department, University of Tübingen, Tübingen, Germany
Michael Meehl, Ambrose Cheung
Department of Microbiology, Dartmouth Medical School, Hanover, New Hampshire, United States of America

Corresponding Author

Email: friedrich.goetz@uni-tuebingen.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

SH and FG conceived and designed the experiments and wrote the paper. SH and DK performed the experiments. SH, CN, and FG analyzed the data. SH, AB, AP, CG, MM, AC, and FG contributed reagents/materials/analysis tools.