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Research Article

A Mycobacterium ESX-1–Secreted Virulence Factor with Unique Requirements for Export

  • Bryant McLaughlin,

    Affiliations: Program in Microbial Pathogenesis and Host Defense, University of California San Francisco, San Francisco, California, United States of America, Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America

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  • Janet S Chon,

    Affiliation: Program in Microbial Pathogenesis and Host Defense, University of California San Francisco, San Francisco, California, United States of America

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  • Jason A MacGurn,

    Affiliation: Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America

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  • Fredric Carlsson,

    Affiliation: Program in Microbial Pathogenesis and Host Defense, University of California San Francisco, San Francisco, California, United States of America

    ¤ Current address: Department of Microbial Pathogenesis, Genentech, South San Francisco, California, United States of America

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  • Terri L Cheng,

    Affiliation: Program in Microbial Pathogenesis and Host Defense, University of California San Francisco, San Francisco, California, United States of America

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  • Jeffery S Cox,

    Affiliation: Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America

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  • Eric J Brown mail

    To whom correspondence should be addressed. E-mail: brown.eric@gene.com

    Affiliations: Program in Microbial Pathogenesis and Host Defense, University of California San Francisco, San Francisco, California, United States of America, Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America

    ¤ Current address: Department of Microbial Pathogenesis, Genentech, South San Francisco, California, United States of America

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  • Published: August 03, 2007
  • DOI: 10.1371/journal.ppat.0030105

About the Authors

Bryant McLaughlin, Janet S Chon, Fredric Carlsson, Terri L Cheng, Eric J Brown
Program in Microbial Pathogenesis and Host Defense, University of California San Francisco, San Francisco, California, United States of America
Bryant McLaughlin, Jason A MacGurn, Jeffery S Cox, Eric J Brown
Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America

Corresponding Author

Email: brown.eric@gene.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

BM and EJB conceived and designed the experiments and analyzed the data. BM, JSC, JAM, and TLC performed the experiments. BM, JAM, FC, JSC, and EJB contributed reagents/materials/analysis tools. BM, FC, JSC, and EJB wrote the paper.