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Research Article

Coronavirus Non-Structural Protein 1 Is a Major Pathogenicity Factor: Implications for the Rational Design of Coronavirus Vaccines

  • Roland Züst,

    Affiliation: Research Department, Kantonal Hospital St. Gallen, St. Gallen, Switzerland

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  • Luisa Cervantes-Barragán,

    Affiliations: Research Department, Kantonal Hospital St. Gallen, St. Gallen, Switzerland, Unidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, México City, México

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  • Thomas Kuri,

    Affiliation: Department of Virology, University of Freiburg, Freiburg, Germany

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  • Gjon Blakqori,

    Affiliation: Department of Virology, University of Freiburg, Freiburg, Germany

    ¤ Current address: Centre for Biomolecular Sciences, School of Biology, University of St. Andrews, North Haugh, St. Andrews, Scotland, United Kingdom

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  • Friedemann Weber,

    Affiliation: Department of Virology, University of Freiburg, Freiburg, Germany

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  • Burkhard Ludewig,

    Affiliation: Research Department, Kantonal Hospital St. Gallen, St. Gallen, Switzerland

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  • Volker Thiel mail

    To whom correspondence should be addressed. E-mail: volker.thiel@kssg.ch

    Affiliation: Research Department, Kantonal Hospital St. Gallen, St. Gallen, Switzerland

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  • Published: August 10, 2007
  • DOI: 10.1371/journal.ppat.0030109

About the Authors

Roland Züst, Luisa Cervantes-Barragán, Burkhard Ludewig, Volker Thiel
Research Department, Kantonal Hospital St. Gallen, St. Gallen, Switzerland
Luisa Cervantes-Barragán
Unidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, México City, México
Thomas Kuri, Gjon Blakqori, Friedemann Weber
Department of Virology, University of Freiburg, Freiburg, Germany

Corresponding Author

Email: volker.thiel@kssg.ch

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

FW, BL, and VT conceived and designed the experiments. RZ, LCB, TK, and GB performed the experiments. All authors analyzed the data. RZ, FW, BL, and VT wrote the paper.