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Research Article

Mycobacterium tuberculosis nuoG Is a Virulence Gene That Inhibits Apoptosis of Infected Host Cells

  • Kamalakannan Velmurugan,

    Affiliation: Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, United States of America

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  • Bing Chen,

    Affiliation: Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, New York, United States of America

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  • Jessica L Miller,

    Affiliation: Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, United States of America

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  • Sharon Azogue,

    Affiliation: Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, United States of America

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  • Serdar Gurses,

    Affiliation: Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, United States of America

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  • Tsungda Hsu,

    Affiliation: Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, New York, United States of America

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  • Michael Glickman,

    Affiliation: Division of Infectious Diseases, Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America

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  • William R Jacobs Jr.,

    Affiliations: Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, New York, United States of America, Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America

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  • Steven A Porcelli,

    Affiliations: Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America

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  • Volker Briken mail

    To whom correspondence should be addressed. E-mail: vbriken@umd.edu

    Affiliation: Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, United States of America

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  • Published: July 20, 2007
  • DOI: 10.1371/journal.ppat.0030110

About the Authors

Kamalakannan Velmurugan, Jessica L Miller, Sharon Azogue, Serdar Gurses, Volker Briken
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, United States of America
Bing Chen, Tsungda Hsu, William R Jacobs Jr.
Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, New York, United States of America
Michael Glickman
Division of Infectious Diseases, Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
William R Jacobs Jr., Steven A Porcelli
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America
William R Jacobs Jr., Steven A Porcelli
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America

Corresponding Author

Email: vbriken@umd.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

KV, JM, SA, SG, and VB conceived and designed the experiments. KV, BC, JM, SA, SG, and VB performed the experiments. KV, WRJ, SAP, and VB analyzed the data. TH, MG, and WRJ contributed reagents/materials/analysis tools. SAP and VB wrote the paper.