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Research Article

Differential Regulation of Caspase-1 Activation, Pyroptosis, and Autophagy via Ipaf and ASC in Shigella-Infected Macrophages

  • Toshihiko Suzuki mail,

    To whom correspondence should be addressed. E-mail: t-suzuki@med.u-ryukyu.ac.jp (TS), bclx@umich.edu (GN)

    Affiliation: Division of Bacterial Pathogenesis, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan

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  • Luigi Franchi,

    Affiliation: Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • Claudia Toma,

    Affiliation: Division of Bacterial Pathogenesis, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan

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  • Hiroshi Ashida,

    Affiliation: Department of Microbiology and Immunology, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan

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  • Michinaga Ogawa,

    Affiliation: Department of Microbiology and Immunology, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan

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  • Yuko Yoshikawa,

    Affiliation: Department of Microbiology and Immunology, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan

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  • Hitomi Mimuro,

    Affiliation: Department of Microbiology and Immunology, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan

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  • Naohiro Inohara,

    Affiliation: Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • Chihiro Sasakawa,

    Affiliations: Department of Microbiology and Immunology, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan, Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kawaguchi, Japan

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  • Gabriel Nuñez mail

    To whom correspondence should be addressed. E-mail: t-suzuki@med.u-ryukyu.ac.jp (TS), bclx@umich.edu (GN)

    Affiliation: Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • Published: August 10, 2007
  • DOI: 10.1371/journal.ppat.0030111

About the Authors

Toshihiko Suzuki, Claudia Toma
Division of Bacterial Pathogenesis, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
Luigi Franchi, Naohiro Inohara, Gabriel Nuñez
Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
Hiroshi Ashida, Michinaga Ogawa, Yuko Yoshikawa, Hitomi Mimuro, Chihiro Sasakawa
Department of Microbiology and Immunology, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Chihiro Sasakawa
Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Chihiro Sasakawa
Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kawaguchi, Japan

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

TS designed the research. TS, LF, CT, HA, MO, YY, and HM performed the research. TS, NI, CS, and GN analyzed the data. TS and GN wrote the paper.