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Research Article

In Vitro and In Vivo Neurotoxicity of Prion Protein Oligomers

  • Steve Simoneau,

    Affiliation: Commissariat à l'Energie Atomique, Fontenay-aux-Roses, France

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  • Human Rezaei,

    Affiliation: Institut National de la Recherche Agronomique, Jouy-en-Josas, France

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  • Nicole Salès,

    Affiliation: Department of Infectology, The Scripps Research Institute, Jupiter, Florida, United States of America

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  • Gunnar Kaiser-Schulz,

    Affiliation: Institute of Virology, Technical University of Munich, Munich, Germany

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  • Maxime Lefebvre-Roque,

    Affiliations: Commissariat à l'Energie Atomique, Fontenay-aux-Roses, France, Department of Infectology, The Scripps Research Institute, Jupiter, Florida, United States of America

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  • Catherine Vidal,

    Affiliation: Institut Pasteur, Paris, France

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  • Jean-Guy Fournier,

    Affiliation: Commissariat à l'Energie Atomique, Fontenay-aux-Roses, France

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  • Julien Comte,

    Affiliation: Commissariat à l'Energie Atomique, Fontenay-aux-Roses, France

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  • Franziska Wopfner,

    Affiliation: Institute of Virology, Technical University of Munich, Munich, Germany

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  • Jeanne Grosclaude,

    Affiliation: Institut National de la Recherche Agronomique, Jouy-en-Josas, France

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  • Hermann Schätzl,

    Affiliation: Institute of Virology, Technical University of Munich, Munich, Germany

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  • Corinne Ida Lasmézas mail

    To whom correspondence should be addressed. E-mail: lasmezas@scripps.edu

    Affiliation: Department of Infectology, The Scripps Research Institute, Jupiter, Florida, United States of America

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  • Published: August 31, 2007
  • DOI: 10.1371/journal.ppat.0030125

About the Authors

Steve Simoneau, Maxime Lefebvre-Roque, Jean-Guy Fournier, Julien Comte
Commissariat à l'Energie Atomique, Fontenay-aux-Roses, France
Human Rezaei, Jeanne Grosclaude
Institut National de la Recherche Agronomique, Jouy-en-Josas, France
Nicole Salès, Maxime Lefebvre-Roque, Corinne Ida Lasmézas
Department of Infectology, The Scripps Research Institute, Jupiter, Florida, United States of America
Gunnar Kaiser-Schulz, Franziska Wopfner, Hermann Schätzl
Institute of Virology, Technical University of Munich, Munich, Germany
Catherine Vidal
Institut Pasteur, Paris, France

Corresponding Author

Email: lasmezas@scripps.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

SS and CIL conceived and designed the experiments and wrote the paper. SS, HR, NS, GKS, MLR, CV, JGF, JC, and FW performed the experiments. SS, JG, HS, and CIL analyzed the data. HR and HS contributed reagents/materials/analysis tools.