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Research Article

Inhibitors of Pathogen Intercellular Signals as Selective Anti-Infective Compounds

  • Biliana Lesic,

    Affiliations: Department of Surgery, Microbiology and Molecular Genetics, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Shriners Burns Institute, Boston, Massachusetts, United States of America

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  • François Lépine,

    Affiliation: INRS-Institut Armand-Frappier, Laval, Québec, Canada

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  • Eric Déziel,

    Affiliation: INRS-Institut Armand-Frappier, Laval, Québec, Canada

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  • Jiangwen Zhang,

    Affiliation: Bauer Center for Genomics Research, Harvard University, Cambridge, Massachusetts, United States of America

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  • Qunhao Zhang,

    Affiliations: Department of Surgery, Microbiology and Molecular Genetics, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Shriners Burns Institute, Boston, Massachusetts, United States of America

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  • Katie Padfield,

    Affiliations: Department of Surgery, Microbiology and Molecular Genetics, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Shriners Burns Institute, Boston, Massachusetts, United States of America

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  • Marie-Hélène Castonguay,

    Affiliation: INRS-Institut Armand-Frappier, Laval, Québec, Canada

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  • Sylvain Milot,

    Affiliation: INRS-Institut Armand-Frappier, Laval, Québec, Canada

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  • Scott Stachel,

    Affiliation: Department of Surgery, Microbiology and Molecular Genetics, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • A. Aria Tzika,

    Affiliations: Department of Surgery, Microbiology and Molecular Genetics, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Shriners Burns Institute, Boston, Massachusetts, United States of America

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  • Ronald G Tompkins,

    Affiliations: Department of Surgery, Microbiology and Molecular Genetics, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Shriners Burns Institute, Boston, Massachusetts, United States of America

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  • Laurence G Rahme mail

    To whom correspondence should be addressed. E-mail: rahme@amber.mgh.harvard.edu

    Affiliations: Department of Surgery, Microbiology and Molecular Genetics, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Shriners Burns Institute, Boston, Massachusetts, United States of America

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  • Published: September 14, 2007
  • DOI: 10.1371/journal.ppat.0030126

About the Authors

Biliana Lesic, Qunhao Zhang, Katie Padfield, Scott Stachel, A. Aria Tzika, Ronald G Tompkins, Laurence G Rahme
Department of Surgery, Microbiology and Molecular Genetics, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Biliana Lesic, Laurence G Rahme
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
Biliana Lesic, Qunhao Zhang, Katie Padfield, A. Aria Tzika, Ronald G Tompkins, Laurence G Rahme
Shriners Burns Institute, Boston, Massachusetts, United States of America
François Lépine, Eric Déziel, Marie-Hélène Castonguay, Sylvain Milot
INRS-Institut Armand-Frappier, Laval, Québec, Canada
Jiangwen Zhang
Bauer Center for Genomics Research, Harvard University, Cambridge, Massachusetts, United States of America

Corresponding Author

Email: rahme@amber.mgh.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

BL, FL, ED, AAT, and LGR conceived and designed experiments. BL, FL, ED, QZ, KP, MHC, and SM performed experiments. BL, FL, ED, JZ, AAT, RGT, and LGR analyzed the data. BL, SS, and LGR wrote the manuscript.