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Research Article

Growth of H5N1 Influenza A Viruses in the Upper Respiratory Tracts of Mice

  • Masato Hatta equal contributor,

    equal contributor Contributed equally to this work with: Masato Hatta, Yasuko Hatta

    Affiliation: Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Yasuko Hatta equal contributor,

    equal contributor Contributed equally to this work with: Masato Hatta, Yasuko Hatta

    Affiliation: Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Jin Hyun Kim,

    Affiliation: Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Shinji Watanabe,

    Affiliation: Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Kyoko Shinya,

    Affiliation: The Avian Zoonosis Research Centre, Tottori University, Tottori, Japan

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  • Tung Nguyen,

    Affiliation: National Centre for Veterinary Diagnostics, Hanoi, Vietnam

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  • Phuong Song Lien,

    Affiliation: Vietnam Veterinary Association, Hanoi, Vietnam

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  • Quynh Mai Le,

    Affiliation: National Institute of Hygiene and Epidemiology, Hanoi, Vietnam

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  • Yoshihiro Kawaoka mail

    To whom correspondence should be addressed. E-mail: kawaokay@svm.vetmed.wisc.edu

    Affiliations: Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Institute of Medical Science, University of Tokyo, Tokyo, Japan, Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan

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  • Published: October 05, 2007
  • DOI: 10.1371/journal.ppat.0030133

About the Authors

Masato Hatta, Yasuko Hatta, Jin Hyun Kim, Shinji Watanabe, Yoshihiro Kawaoka
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
Kyoko Shinya
The Avian Zoonosis Research Centre, Tottori University, Tottori, Japan
Tung Nguyen
National Centre for Veterinary Diagnostics, Hanoi, Vietnam
Phuong Song Lien
Vietnam Veterinary Association, Hanoi, Vietnam
Quynh Mai Le
National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
Yoshihiro Kawaoka
Institute of Medical Science, University of Tokyo, Tokyo, Japan
Yoshihiro Kawaoka
Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan

Corresponding Author

Email: kawaokay@svm.vetmed.wisc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

MH, YH, SW, and YK conceived and designed the experiments. MH, YH, JHK, SW, KS, and QML performed the experiments. TN and PSL provided reagents/materials/analysis tools. MH, YH, and JHK performed the cloning experiments. MH, YH, and YK analyzed the data and wrote the paper.