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Research Article

Members of a Large Retroposon Family Are Determinants of Post-Transcriptional Gene Expression in Leishmania

  • Frédéric Bringaud equal contributor mail,

    equal contributor Contributed equally to this work with: Frédéric Bringaud, Michaela Müller

    To whom correspondence should be addressed. E-mail: bringaud@u-bordeaux2.fr (FB); barbara.papadopoulou@crchul.ulaval.ca (BP); ghedine@dom.pitt.edu (EG)

    Affiliations: Laboratoire de Génomique Fonctionnelle des Trypanosomatides, Université Victor Segalen Bordeaux 2, Bordeaux, France, UMR-5234 CNRS, Bordeaux, France

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  • Michaela Müller equal contributor,

    equal contributor Contributed equally to this work with: Frédéric Bringaud, Michaela Müller

    Affiliations: Infectious Diseases Research Center, Centre Hospitalier de l'Université Laval Research Center, Quebec, Canada, Department of Medical Biology, Faculty of Medicine, Laval University, Quebec, Canada

    X
  • Gustavo Coutinho Cerqueira,

    Affiliations: The Institute for Genomic Research, Rockville, Maryland, United States of America, Departamento de Bioquimica e Imunologica, Universidade Federal de Minas Gerais, Minas Gerais, Brazil

    X
  • Martin Smith,

    Affiliations: Infectious Diseases Research Center, Centre Hospitalier de l'Université Laval Research Center, Quebec, Canada, Department of Medical Biology, Faculty of Medicine, Laval University, Quebec, Canada

    X
  • Annie Rochette,

    Affiliations: Infectious Diseases Research Center, Centre Hospitalier de l'Université Laval Research Center, Quebec, Canada, Department of Medical Biology, Faculty of Medicine, Laval University, Quebec, Canada

    X
  • Najib M. A El-Sayed,

    Affiliations: The Institute for Genomic Research, Rockville, Maryland, United States of America, Department of Cell Biology and Molecular Genetics, The University of Maryland, College Park, Maryland, United States of America, Center for Bioinformatics and Computational Biology, The University of Maryland, College Park, Maryland, United States of America

    X
  • Barbara Papadopoulou mail,

    To whom correspondence should be addressed. E-mail: bringaud@u-bordeaux2.fr (FB); barbara.papadopoulou@crchul.ulaval.ca (BP); ghedine@dom.pitt.edu (EG)

    Affiliations: Infectious Diseases Research Center, Centre Hospitalier de l'Université Laval Research Center, Quebec, Canada, Department of Medical Biology, Faculty of Medicine, Laval University, Quebec, Canada

    X
  • Elodie Ghedin mail

    To whom correspondence should be addressed. E-mail: bringaud@u-bordeaux2.fr (FB); barbara.papadopoulou@crchul.ulaval.ca (BP); ghedine@dom.pitt.edu (EG)

    Affiliations: The Institute for Genomic Research, Rockville, Maryland, United States of America, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

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  • Published: September 28, 2007
  • DOI: 10.1371/journal.ppat.0030136

About the Authors

Frédéric Bringaud
Laboratoire de Génomique Fonctionnelle des Trypanosomatides, Université Victor Segalen Bordeaux 2, Bordeaux, France
Frédéric Bringaud
UMR-5234 CNRS, Bordeaux, France
Michaela Müller, Martin Smith, Annie Rochette, Barbara Papadopoulou
Infectious Diseases Research Center, Centre Hospitalier de l'Université Laval Research Center, Quebec, Canada
Michaela Müller, Martin Smith, Annie Rochette, Barbara Papadopoulou
Department of Medical Biology, Faculty of Medicine, Laval University, Quebec, Canada
Gustavo Coutinho Cerqueira, Najib M. A El-Sayed, Elodie Ghedin
The Institute for Genomic Research, Rockville, Maryland, United States of America
Gustavo Coutinho Cerqueira
Departamento de Bioquimica e Imunologica, Universidade Federal de Minas Gerais, Minas Gerais, Brazil
Najib M. A El-Sayed
Department of Cell Biology and Molecular Genetics, The University of Maryland, College Park, Maryland, United States of America
Najib M. A El-Sayed
Center for Bioinformatics and Computational Biology, The University of Maryland, College Park, Maryland, United States of America
Elodie Ghedin
Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

FB, GCC, MS, NMAES, and EG performed the bioinformatic analyses. MM, AR, and BP conceived and designed the biological experiments.