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Research Article

A Viral Nanoparticle with Dual Function as an Anthrax Antitoxin and Vaccine

  • Darly J Manayani,

    Affiliation: Department of Molecular Biology, The Scripps Research Institute, La Jolla, California , United States of America

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  • Diane Thomas,

    Affiliation: Department of Cell Biology, The Scripps Research Institute, La Jolla, California , United States of America

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  • Kelly A Dryden,

    Affiliation: Department of Cell Biology, The Scripps Research Institute, La Jolla, California , United States of America

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  • Vijay Reddy,

    Affiliation: Department of Molecular Biology, The Scripps Research Institute, La Jolla, California , United States of America

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  • Marc E Siladi,

    Affiliation: Department of Molecular Biology, The Scripps Research Institute, La Jolla, California , United States of America

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  • John M Marlett,

    Affiliation: The Salk Institute for Biological Studies, La Jolla, California, United States of America

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  • G. Jonah A Rainey,

    Affiliation: The Salk Institute for Biological Studies, La Jolla, California, United States of America

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  • Michael E Pique,

    Affiliation: Department of Molecular Biology, The Scripps Research Institute, La Jolla, California , United States of America

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  • Heather M Scobie,

    Affiliation: The Salk Institute for Biological Studies, La Jolla, California, United States of America

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  • Mark Yeager,

    Affiliations: Department of Molecular Biology, The Scripps Research Institute, La Jolla, California , United States of America, Department of Cell Biology, The Scripps Research Institute, La Jolla, California , United States of America, Division of Cardiovascular Diseases, Scripps Clinic, La Jolla, California, United States of America

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  • John A. T Young,

    Affiliation: The Salk Institute for Biological Studies, La Jolla, California, United States of America

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  • Marianne Manchester,

    Affiliation: Department of Cell Biology, The Scripps Research Institute, La Jolla, California , United States of America

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  • Anette Schneemann mail

    To whom correspondence should be addressed. E-mail: aschneem@scripps.edu

    Affiliation: Department of Molecular Biology, The Scripps Research Institute, La Jolla, California , United States of America

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  • Published: October 05, 2007
  • DOI: 10.1371/journal.ppat.0030142

About the Authors

Darly J Manayani, Vijay Reddy, Marc E Siladi, Michael E Pique, Mark Yeager, Anette Schneemann
Department of Molecular Biology, The Scripps Research Institute, La Jolla, California , United States of America
Diane Thomas, Kelly A Dryden, Mark Yeager, Marianne Manchester
Department of Cell Biology, The Scripps Research Institute, La Jolla, California , United States of America
John M Marlett, G. Jonah A Rainey, Heather M Scobie, John A. T Young
The Salk Institute for Biological Studies, La Jolla, California, United States of America
Mark Yeager
Division of Cardiovascular Diseases, Scripps Clinic, La Jolla, California, United States of America

Corresponding Author

Email: aschneem@scripps.edu

Competing Interests

The JATY declares competing financial interests. He is a scientific founder of the company PharmAthene Inc.

Author Contributions

DJM, MY, JATY, MM, and AS conceived and designed the experiments. DJM, DT, KAD, VR, MES, JMM, and GJAR performed the experiments. DJM, DT, KAD, VR, MES, JMM, MY, JATY, MM, and AS analyzed the data. MEP and HMS contributed reagents and analysis tools. DJM, MY, JATY, MM, and AS wrote the paper.