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Research Article

Malaria Impairs T Cell Clustering and Immune Priming despite Normal Signal 1 from Dendritic Cells

  • Owain R Millington,

    Affiliation: Centre for Biophotonics, University of Strathclyde, Glasgow, United Kingdom

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  • Vivienne B Gibson,

    Affiliation: Centre for Biophotonics, University of Strathclyde, Glasgow, United Kingdom

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  • Catherine M Rush,

    Affiliation: Centre for Biophotonics, University of Strathclyde, Glasgow, United Kingdom

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  • Bernd H Zinselmeyer,

    Affiliation: Centre for Biophotonics, University of Strathclyde, Glasgow, United Kingdom

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  • R. Stephen Phillips,

    Affiliation: Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom

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  • Paul Garside,

    Affiliation: Centre for Biophotonics, University of Strathclyde, Glasgow, United Kingdom

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  • James M Brewer mail

    To whom correspondence should be addressed. E-mail: james.brewer@strath.ac.uk

    Affiliation: Centre for Biophotonics, University of Strathclyde, Glasgow, United Kingdom

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  • Published: October 12, 2007
  • DOI: 10.1371/journal.ppat.0030143

About the Authors

Owain R Millington, Vivienne B Gibson, Catherine M Rush, Bernd H Zinselmeyer, Paul Garside, James M Brewer
Centre for Biophotonics, University of Strathclyde, Glasgow, United Kingdom
R. Stephen Phillips
Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom

Corresponding Author

Email: james.brewer@strath.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

ORM, RSP, PG, and JMB conceived and designed the experiments and wrote the paper. ORM and VBG performed the experiments and analyzed the data. CMR and BHZ contributed reagents/materials/analysis tools.