Advertisement
Research Article

The Transcription Factor Mrr1p Controls Expression of the MDR1 Efflux Pump and Mediates Multidrug Resistance in Candida albicans

  • Joachim Morschhäuser mail,

    To whom correspondence should be addressed. E-mail: joachim.morschhaeuser@mail.uni-wuerzburg.de

    Affiliation: Institut für Molekulare Infektionsbiologie, Universität Würzburg, Würzburg, Germany

    X
  • Katherine S Barker,

    Affiliations: Department of Clinical Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Children's Foundation Research Center at Le Bonheur Children's Medical Center, Memphis, Tennessee, United States of America

    X
  • Teresa T Liu,

    Affiliation: Department of Clinical Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

    X
  • Julia Blaß-Warmuth,

    Affiliation: Institut für Molekulare Infektionsbiologie, Universität Würzburg, Würzburg, Germany

    X
  • Ramin Homayouni,

    Affiliation: Bioinformatics Program, Department of Biology, University of Memphis, Memphis, Tennessee, United States of America

    X
  • P. David Rogers

    Affiliations: Department of Clinical Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Children's Foundation Research Center at Le Bonheur Children's Medical Center, Memphis, Tennessee, United States of America, Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

    X
  • Published: November 02, 2007
  • DOI: 10.1371/journal.ppat.0030164

About the Authors

Joachim Morschhäuser, Julia Blaß-Warmuth
Institut für Molekulare Infektionsbiologie, Universität Würzburg, Würzburg, Germany
Katherine S Barker, Teresa T Liu, P. David Rogers
Department of Clinical Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
Katherine S Barker, P. David Rogers
Children's Foundation Research Center at Le Bonheur Children's Medical Center, Memphis, Tennessee, United States of America
Ramin Homayouni
Bioinformatics Program, Department of Biology, University of Memphis, Memphis, Tennessee, United States of America
P. David Rogers
Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
P. David Rogers
Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
P. David Rogers
Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

Corresponding Author

Email: joachim.morschhaeuser@mail.uni-wuerzburg.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JM and PDR conceived and designed the experiments and wrote the paper. KSB, TTL, and JBW performed the experiments. JM, RH, and PDR analyzed the data.