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Research Article

Vaccine Escape Recombinants Emerge after Pneumococcal Vaccination in the United States

  • Angela B Brueggemann mail,

    To whom correspondence should be addressed. E-mail: angela.brueggemann@zoo.ox.ac.uk

    Affiliation: Department of Zoology, University of Oxford, Oxford, United Kingdom

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  • Rekha Pai,

    Affiliation: Department of Gastrointestinal Sciences, Christian Medical College, Vellore, India

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  • Derrick W Crook,

    Affiliation: Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, United Kingdom

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  • Bernard Beall

    Affiliation: Centers for Disease Control, Atlanta, Georgia, United States of America

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  • Published: November 16, 2007
  • DOI: 10.1371/journal.ppat.0030168

About the Authors

Angela B Brueggemann
Department of Zoology, University of Oxford, Oxford, United Kingdom
Rekha Pai
Department of Gastrointestinal Sciences, Christian Medical College, Vellore, India
Derrick W Crook
Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, United Kingdom
Bernard Beall
Centers for Disease Control, Atlanta, Georgia, United States of America

Corresponding Author

Email: angela.brueggemann@zoo.ox.ac.uk

Competing Interests

Angela B. Brueggemann has been an advisor to Wyeth Vaccines and GlaxoSmithKline Biologicals and has received grant funding from both companies; Derrick W. Crook has received grant funding from Wyeth Vaccines.

Author Contributions

ABB performed the molecular work, analyzed the data, and wrote the manuscript. RP and BB were responsible for phenotypic characterisation of the strains and MLST genotyping. All authors contributed to the design of the study, discussed the results, and commented on the manuscript.