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Research Article

Predominant Infection of CD150+ Lymphocytes and Dendritic Cells during Measles Virus Infection of Macaques

  • Rik L de Swart mail,

    To whom correspondence should be addressed. E-mail: r.deswart@erasmusmc.nl

    Affiliation: Department of Virology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands

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  • Martin Ludlow equal contributor,

    equal contributor Contributed equally to this work with: Martin Ludlow, Lot de Witte

    Affiliation: School of Biomedical Sciences, Queen's University of Belfast, United Kingdom

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  • Lot de Witte equal contributor,

    equal contributor Contributed equally to this work with: Martin Ludlow, Lot de Witte

    Affiliation: Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands

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  • Yusuke Yanagi,

    Affiliation: Department of Virology, Kyushu University, Fukuoka, Japan

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  • Geert van Amerongen,

    Affiliation: Department of Virology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands

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  • Stephen McQuaid,

    Affiliation: School of Biomedical Sciences, Queen's University of Belfast, United Kingdom

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  • Selma Yüksel,

    Affiliation: Department of Virology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands

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  • Teunis B. H Geijtenbeek,

    Affiliation: Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands

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  • W. Paul Duprex,

    Affiliation: School of Biomedical Sciences, Queen's University of Belfast, United Kingdom

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  • Albert D. M. E Osterhaus

    Affiliation: Department of Virology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands

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  • Published: November 16, 2007
  • DOI: 10.1371/journal.ppat.0030178

About the Authors

Rik L de Swart, Geert van Amerongen, Selma Yüksel, Albert D. M. E Osterhaus
Department of Virology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
Martin Ludlow, Stephen McQuaid, W. Paul Duprex
School of Biomedical Sciences, Queen's University of Belfast, United Kingdom
Lot de Witte, Teunis B. H Geijtenbeek
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
Yusuke Yanagi
Department of Virology, Kyushu University, Fukuoka, Japan

Corresponding Author

Email: r.deswart@erasmusmc.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

ML and LdW contributed equally to this study. RLdS, TBHG, WPD, and ADMEO designed and planned the study. RLdS coordinated the study and wrote the manuscript, to which all authors provided feedback. All authors approved the final version of the manuscript. RLdS and GvA undertook the infection experiments and obtained study samples and macroscopic images. YY provided the plasmid from which the recombinant virus was rescued. RLdS and SY performed the virological and serological experiments and the FACS assays. RLdS prepared Figures 1–4, Tables S1–S3, and Figures S1 and S2. LdW performed virus detection assays in samples from skin and mouth and prepared Figures 5 and S3. ML and SM performed virus detection assays in other organs and prepared Figures 6 and S4.