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Research Article

Hemolytic C-Type Lectin CEL-III from Sea Cucumber Expressed in Transgenic Mosquitoes Impairs Malaria Parasite Development

  • Shigeto Yoshida mail,

    To whom correspondence should be addressed. E-mail: shigeto@jichi.ac.jp

    Affiliation: Division of Medical Zoology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan

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  • Yohei Shimada,

    Affiliation: Division of Medical Zoology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan

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  • Daisuke Kondoh,

    Affiliation: Division of Medical Zoology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan

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  • Yoshiaki Kouzuma,

    Affiliation: College of Agriculture, Ibaraki University, Ami-machi, Inashiki-gun, Ibaraki, Japan

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  • Anil K Ghosh,

    Affiliation: Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins School of Public Health, Baltimore, Maryland, United States of America

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  • Marcelo Jacobs-Lorena,

    Affiliation: Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins School of Public Health, Baltimore, Maryland, United States of America

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  • Robert E Sinden

    Affiliation: Infection and Immunity Section, Division of Cell and Molecular Biology, Imperial College London, South Kensington, London, United Kingdom

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  • Published: December 21, 2007
  • DOI: 10.1371/journal.ppat.0030192

About the Authors

Shigeto Yoshida, Yohei Shimada, Daisuke Kondoh
Division of Medical Zoology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan
Yoshiaki Kouzuma
College of Agriculture, Ibaraki University, Ami-machi, Inashiki-gun, Ibaraki, Japan
Anil K Ghosh, Marcelo Jacobs-Lorena
Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins School of Public Health, Baltimore, Maryland, United States of America
Robert E Sinden
Infection and Immunity Section, Division of Cell and Molecular Biology, Imperial College London, South Kensington, London, United Kingdom

Corresponding Author

Email: shigeto@jichi.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

SY conceived and designed the experiments. All authors performed the experiments. SY, MJL, and RES analyzed the data and wrote the paper.